Untargeted metabolomic analysis of human serum samples associated with different levels of red meat consumption: A possible indicator of type 2 diabetes?

Daniel Carrizo*, Olivier P. Chevallier, Jayne V. Woodside, Sarah F. Brennan, Marie M. Cantwell, Geraldine Cuskelly, Christopher T. Elliott

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)
300 Downloads (Pure)

Abstract

Red meat consumption has been associated with negative health effects. A study to identify biomarkers of meat consumption was undertaken using serum samples collected from combining high resolution mass spectrometry (UPLC-QTof-MS) and chemometrics. Using orthogonal partial last-squares discriminant analysis (OPLS-DA), multivariate models were created for both modes of acquisition (ESI−/ESI+) and red meat intake classes (YES/NO). In the serum samples, a total 3280 and 3225 ions of interest were detected in positive and negative modes, respectively. Of these, 62 were found to be significantly different (p < 0.05) between the two groups. Glycerophospholipids as well as other family lipids, such as lysophospholipids or sphingomyelin, were found significantly (p < 0.05) different between yes and no red meat intake groups. This study has shown metabolomics fingerprints have the capability to identify potential biomarkers of red meat consumption, as well as possible health risk factors (e.g., key metabolic families related to the risk of development type 2 diabetes).

Original languageEnglish
Number of pages8
JournalFood Chemistry
Early online date13 Oct 2016
DOIs
Publication statusEarly online date - 13 Oct 2016

Keywords

  • Biomarkers analysis
  • Diabetes
  • Health risk factors
  • Lipids
  • Metabolomics
  • Red meat consumption
  • UPLC-QTof-MS

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science
  • Medicine(all)

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