Update on paramyosin in parasitic worms

Geoffrey N. Gobert, Donald P. McManus

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Paramyosin was first identified as a structural component of invertebrate muscle. Analysis of crude, native, adult schistosome worm preparations identified a highly immunogenic protein which was later identified as paramyosin. Early vaccination/challenge studies with native paramyosin produced encouraging levels of protective efficacy against schistosomes, which led to the question as to how a sub-tegumental (muscular) protein could provide a target for vaccine-mediated immunological attack. Immunolocalisation studies of schistosomes confirmed the presence of paramyosin within the post-acetabular glands of cercariae and on the tegumental surface of lung schistosomula. Here we present an update on the more recent research on paramyosin in parasitic worms that has focused primarily in two directions: (i) further testing of the vaccine potency of paramyosin against schistosomes and other parasitic worms; and (ii) characterisation of the protein at the molecular and biochemical levels.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalParasitology International
Volume54
Issue number2
DOIs
Publication statusPublished - 01 Jan 2005
Externally publishedYes

Keywords

  • Paramyosin
  • Schistosome
  • Surface protein
  • Vaccine target

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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