Upregulation of adrenomedullin and its receptor components during cardiomyocyte hypertrophy induced by chronic inhibition of nitric oxide synthesis in rats

David Bell, Y.Y. Zhao, Elizabeth Kelso, E.M. McHenry, L.M. Rush, V.M. Lamont, D.P. Nicholls, Barbara McDermott

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Adrenomedullin may provide a compensatory mechanism to attenuate left ventricular hypertrophy (LVH). Nitric oxide synthase inhibition, induced by chronic administration of N(omega)-nitro-L-arginine methyl ester (L-NAME) to rats, induces cardiac hypertrophy in some, but not all cases; there are few reports of direct assessment of cardiomyocyte parameters. The objective was to characterize hypertrophic parameters in left (LV) and right ventricular (RV) cardiomyocytes after administration of L-NAME to rats for 8 wk and to determine whether adrenomedullin and its receptor components were upregulated. After treatment with L-NAME (20 and 50 mg x kg(-1) x day(-1)), compared with nontreated animals, 1) systolic blood pressure increased (by 34.2 and 104.9 mmHg), 2) heart weight-to-body wt ratio increased 24.1% at the higher dose (P
Original languageEnglish
Pages (from-to)H904-H914
Number of pages11
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume290(2)
Issue number2
DOIs
Publication statusPublished - Feb 2006

ASJC Scopus subject areas

  • Physiology

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