Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study

R. Zamora-Ros; D. Achaintre; J. A. Rothwell; S. Rinaldi; N. Assi; P. Ferrari; M. Leitzmann; M. C. Boutron-Ruault; G. Fagherazzi; A. Auffret; T. Kuhn; V. Katzke; H. Boeing; A. Trichopoulou; A. Naska; E. Vasilopoulou; D. Palli; S. Grioni; A. Mattiello; R. Tumino; F. Ricceri; N. Slimani; I. Romieu; A. Scalbert

doi:10.1038/srep26905

Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study

R. Zamora-Ros, D. Achaintre, J. A. Rothwell, S. Rinaldi, N. Assi, P. Ferrari, M. Leitzmann, M. C. Boutron-Ruault, G. Fagherazzi, A. Auffret, T. Kuhn, V. Katzke, H. Boeing, A. Trichopoulou, A. Naska, E. Vasilopoulou, D. Palli, S. Grioni, A. Mattiello, R. TuminoF. Ricceri, N. Slimani, I. Romieu, A. Scalbert

School of Biological Sciences

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Abstract

Urinary excretion of 34 dietary polyphenols and their variations according to diet and other lifestyle factors were measured by tandem mass spectrometry in 475 adult participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study. A single 24-hour urine sample was analysed for each subject from 4 European countries. The highest median levels were observed for phenolic acids such as 4-hydroxyphenylacetic acid (157μmol/24h), followed by 3-hydroxyphenylacetic, ferulic, vanillic and homovanillic acids (20–50μmol/24h). The lowest concentrations were observed for equol, apigenin and resveratrol (<0.1μmol/24h). Urinary polyphenols significantly varied by centre, followed by alcohol intake, sex, educational level, and energy intake. This variability is largely explained by geographical variations in the diet, as suggested by the high correlations (r>0.5) observed between urinary polyphenols and the intake of their main food sources (e.g., resveratrol and gallic acid ethyl ester with red wine intake; caffeic, protocatechuic and ferulic acids with coffee consumption; and hesperetin and naringenin with citrus fruit intake). The large variations in urinary polyphenols observed are largely determined by food preferences. These polyphenol biomarkers should allow more accurate evaluation of the relationships between polyphenol exposure and the risk of chronic diseases in large epidemiological studies.

Original language	Undefined/Unknown
Article number	26905
Number of pages	9
Journal	Sci Rep
Volume	6
DOIs	https://doi.org/10.1038/srep26905
Publication status	Published - 07 Jun 2016

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10.1038/srep26905

Urinary excretions of 34 dietary polyphenols
© 2016 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
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Zamora-Ros, R., Achaintre, D., Rothwell, J. A., Rinaldi, S., Assi, N., Ferrari, P., Leitzmann, M., Boutron-Ruault, M. C., Fagherazzi, G., Auffret, A., Kuhn, T., Katzke, V., Boeing, H., Trichopoulou, A., Naska, A., Vasilopoulou, E., Palli, D., Grioni, S., Mattiello, A., ... Scalbert, A. (2016). Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study. Sci Rep, 6, [26905]. https://doi.org/10.1038/srep26905

Zamora-Ros, R. ; Achaintre, D. ; Rothwell, J. A. ; Rinaldi, S. ; Assi, N. ; Ferrari, P. ; Leitzmann, M. ; Boutron-Ruault, M. C. ; Fagherazzi, G. ; Auffret, A. ; Kuhn, T. ; Katzke, V. ; Boeing, H. ; Trichopoulou, A. ; Naska, A. ; Vasilopoulou, E. ; Palli, D. ; Grioni, S. ; Mattiello, A. ; Tumino, R. ; Ricceri, F. ; Slimani, N. ; Romieu, I. ; Scalbert, A. / Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study. In: Sci Rep. 2016 ; Vol. 6.

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abstract = "Urinary excretion of 34 dietary polyphenols and their variations according to diet and other lifestyle factors were measured by tandem mass spectrometry in 475 adult participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study. A single 24-hour urine sample was analysed for each subject from 4 European countries. The highest median levels were observed for phenolic acids such as 4-hydroxyphenylacetic acid (157μmol/24h), followed by 3-hydroxyphenylacetic, ferulic, vanillic and homovanillic acids (20–50μmol/24h). The lowest concentrations were observed for equol, apigenin and resveratrol (<0.1μmol/24h). Urinary polyphenols significantly varied by centre, followed by alcohol intake, sex, educational level, and energy intake. This variability is largely explained by geographical variations in the diet, as suggested by the high correlations (r>0.5) observed between urinary polyphenols and the intake of their main food sources (e.g., resveratrol and gallic acid ethyl ester with red wine intake; caffeic, protocatechuic and ferulic acids with coffee consumption; and hesperetin and naringenin with citrus fruit intake). The large variations in urinary polyphenols observed are largely determined by food preferences. These polyphenol biomarkers should allow more accurate evaluation of the relationships between polyphenol exposure and the risk of chronic diseases in large epidemiological studies.",

author = "R. Zamora-Ros and D. Achaintre and Rothwell, {J. A.} and S. Rinaldi and N. Assi and P. Ferrari and M. Leitzmann and Boutron-Ruault, {M. C.} and G. Fagherazzi and A. Auffret and T. Kuhn and V. Katzke and H. Boeing and A. Trichopoulou and A. Naska and E. Vasilopoulou and D. Palli and S. Grioni and A. Mattiello and R. Tumino and F. Ricceri and N. Slimani and I. Romieu and A. Scalbert",

year = "2016",

month = jun,

day = "7",

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Zamora-Ros, R, Achaintre, D, Rothwell, JA, Rinaldi, S, Assi, N, Ferrari, P, Leitzmann, M, Boutron-Ruault, MC, Fagherazzi, G, Auffret, A, Kuhn, T, Katzke, V, Boeing, H, Trichopoulou, A, Naska, A, Vasilopoulou, E, Palli, D, Grioni, S, Mattiello, A, Tumino, R, Ricceri, F, Slimani, N, Romieu, I & Scalbert, A 2016, 'Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study', Sci Rep, vol. 6, 26905. https://doi.org/10.1038/srep26905

Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study. / Zamora-Ros, R.; Achaintre, D.; Rothwell, J. A.; Rinaldi, S.; Assi, N.; Ferrari, P.; Leitzmann, M.; Boutron-Ruault, M. C.; Fagherazzi, G.; Auffret, A.; Kuhn, T.; Katzke, V.; Boeing, H.; Trichopoulou, A.; Naska, A.; Vasilopoulou, E.; Palli, D.; Grioni, S.; Mattiello, A.; Tumino, R.; Ricceri, F.; Slimani, N.; Romieu, I.; Scalbert, A.

In: Sci Rep, Vol. 6, 26905, 07.06.2016.

Research output: Contribution to journal › Article

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T1 - Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study

AU - Zamora-Ros, R.

AU - Achaintre, D.

AU - Rothwell, J. A.

AU - Rinaldi, S.

AU - Assi, N.

AU - Ferrari, P.

AU - Leitzmann, M.

AU - Boutron-Ruault, M. C.

AU - Fagherazzi, G.

AU - Auffret, A.

AU - Kuhn, T.

AU - Katzke, V.

AU - Boeing, H.

AU - Trichopoulou, A.

AU - Naska, A.

AU - Vasilopoulou, E.

AU - Palli, D.

AU - Grioni, S.

AU - Mattiello, A.

AU - Tumino, R.

AU - Ricceri, F.

AU - Slimani, N.

AU - Romieu, I.

AU - Scalbert, A.

PY - 2016/6/7

Y1 - 2016/6/7

N2 - Urinary excretion of 34 dietary polyphenols and their variations according to diet and other lifestyle factors were measured by tandem mass spectrometry in 475 adult participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study. A single 24-hour urine sample was analysed for each subject from 4 European countries. The highest median levels were observed for phenolic acids such as 4-hydroxyphenylacetic acid (157μmol/24h), followed by 3-hydroxyphenylacetic, ferulic, vanillic and homovanillic acids (20–50μmol/24h). The lowest concentrations were observed for equol, apigenin and resveratrol (<0.1μmol/24h). Urinary polyphenols significantly varied by centre, followed by alcohol intake, sex, educational level, and energy intake. This variability is largely explained by geographical variations in the diet, as suggested by the high correlations (r>0.5) observed between urinary polyphenols and the intake of their main food sources (e.g., resveratrol and gallic acid ethyl ester with red wine intake; caffeic, protocatechuic and ferulic acids with coffee consumption; and hesperetin and naringenin with citrus fruit intake). The large variations in urinary polyphenols observed are largely determined by food preferences. These polyphenol biomarkers should allow more accurate evaluation of the relationships between polyphenol exposure and the risk of chronic diseases in large epidemiological studies.

AB - Urinary excretion of 34 dietary polyphenols and their variations according to diet and other lifestyle factors were measured by tandem mass spectrometry in 475 adult participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study. A single 24-hour urine sample was analysed for each subject from 4 European countries. The highest median levels were observed for phenolic acids such as 4-hydroxyphenylacetic acid (157μmol/24h), followed by 3-hydroxyphenylacetic, ferulic, vanillic and homovanillic acids (20–50μmol/24h). The lowest concentrations were observed for equol, apigenin and resveratrol (<0.1μmol/24h). Urinary polyphenols significantly varied by centre, followed by alcohol intake, sex, educational level, and energy intake. This variability is largely explained by geographical variations in the diet, as suggested by the high correlations (r>0.5) observed between urinary polyphenols and the intake of their main food sources (e.g., resveratrol and gallic acid ethyl ester with red wine intake; caffeic, protocatechuic and ferulic acids with coffee consumption; and hesperetin and naringenin with citrus fruit intake). The large variations in urinary polyphenols observed are largely determined by food preferences. These polyphenol biomarkers should allow more accurate evaluation of the relationships between polyphenol exposure and the risk of chronic diseases in large epidemiological studies.

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DO - 10.1038/srep26905

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VL - 6

JO - Nature Scientific Reports

JF - Nature Scientific Reports

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