Urogynecological surgical mesh implants: new trends in materials, manufacturing and therapeutic approaches

Zara-Louise Farmer, Juan Dominguez Robles, Caterina Mancinelli, Eneko Larrañeta*, Dimitrios Lamprou*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI) are two prevalent disorders affecting 30-40% of women worldwide. Current strategies to repair or improve these medical conditions are nonsurgical options such as physiotherapy, or surgical options such as the use of vaginal meshes. The synthetic material polypropylene (PP), which has long been used for manufacturing these vaginal meshes, is associated with severe complications such as chronic pain, infection or mesh erosion. As a result of a widespread reporting and unacceptably high rates of complications, these issues have become a public health concern. Regulatory bodies have recently deemed the transvaginal placement of PP mesh in the pelvic floor (PF) no longer a suitable treatment method for PF repair, leading to the need for a novel approach to the manufacture and selection of materials for urogynecological meshes. Medical devices, such as vaginal meshes can be manufactured using a variety of techniques including injection moulding, electrospinning, hot-melt extrusion (HME) or more recently 3D printing. Over the past decade, the use of 3D printing within the medical device industry has expanded and offers a promising approach to manufacture patient-specific surgical mesh when combined with imaging tools. This review will summarise the current strategies to treat POP and SUI, the issues and use of current meshes for the treatment of these pelvic floor disorders (PFDs), and the future directions for the manufacture of more suitable urogynecological meshes, as well as their potential materials.
Original languageEnglish
JournalInternational Journal of Pharmaceutics
Publication statusAccepted - 04 Jun 2020

Keywords

  • Pelvic organ prolapse
  • stress urinary incontinence
  • surgical mesh
  • extrusion
  • electrospinning
  • implants
  • 3D printing

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