Use of A192621 to provide evidence for involvement of endothelin ET(B)-receptors in endothelin-1-mediated cardiomyocyte hypertrophy.

J.P. Cullen, David Bell, Elizabeth Kelso, Barbara McDermott

Research output: Contribution to journalArticle

Abstract

Increased plasma levels of endothelin-1 correlate with the severity of left ventricular hypertrophy in vivo. The aim of the study was to determine the relative contribution of stimulation of endothelin ETA and endothelin ETB receptors, and the associated activation of protein kinase C, to the hypertrophic response initiated by endothelin-1 in adult rat ventricular cardiomyocytes maintained in culture (24 h). Endothelin-1 (10-7 M) increased the total mass of protein and the incorporation of [14C] phenylalanine into protein to 26% and 25% greater (P
Original languageEnglish
Pages (from-to)157-168
Number of pages12
JournalEuropean Journal of Pharmacology
Volume417
Publication statusPublished - Apr 2001

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