Use of Inhaled Tobramycin in Cystic Fibrosis

Michal Shteinberg*, J. Stuart Elborn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Chronic infection with Pseudomonas aeruginosa is associated with poor outcomes in patients with cystic fibrosis (CF). It leads to a reduced quality of life, acceleration of the decline in lung function, and increased frequency and severity of pulmonary exacerbations. Tobramycin, administered by inhalation as a long-term therapy, decreases bacterial density in airways, reduces exacerbation frequency, and improves quality of life and lung function in patients with chronic P. aeruginosa infection. In the last decade, tobramycin inhalation has become an important contributor to CF treatment as a means to control chronic infection and as a first-line treatment for the eradication of early acquisition of P. aeruginosa. Recently, a dry powder inhalation (DPI) form of tobramycin has become available, which is more convenient for administration and has comparable efficacy to the tobramycin solution. This DPI, the Podhaler™ (Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA), requires less time for treatment delivery and is more portable than a nebulizer, and so is a welcome additional therapeutic option for many patients.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalAdvances in therapy
Volume32
Issue number1
DOIs
Publication statusPublished - 27 Jan 2015

Keywords

  • Cystic fibrosis
  • Dry powder inhalation
  • Pseudomonas aeruginosa
  • Tobramycin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine(all)

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