Use of Voltammetry for in vitro Equilibrium and Transport Studies of Ionisable Drugs

Matěj Velický; Andrew N J Rodgers; Robert A W Dryfe; Kin Y. Tam

doi:10.5599/admet.2.3.22

Use of Voltammetry for in vitro Equilibrium and Transport Studies of Ionisable Drugs

Matěj Velický, Andrew N J Rodgers, Robert A W Dryfe, Kin Y. Tam

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

58 Downloads (Pure)

Abstract

In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusion coefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies.

Original language	English
Pages (from-to)	143-156
Number of pages	13
Journal	ADMET & DMPK
Volume	2
Issue number	3
DOIs	https://doi.org/10.5599/admet.2.3.22
Publication status	Published - 16 Sept 2014
Externally published	Yes

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10.5599/admet.2.3.22Licence: CC BY

Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
Copyright 2014 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.1 MBLicence: Unspecified

Cite this

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abstract = "In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusion coefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies.",

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AB - In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusion coefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies.

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DO - 10.5599/admet.2.3.22

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Use of Voltammetry for in vitro Equilibrium and Transport Studies of Ionisable Drugs

Abstract

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