Use of Voltammetry for in vitro Equilibrium and Transport Studies of Ionisable Drugs

Matěj Velický, Andrew N J Rodgers, Robert A W Dryfe, Kin Y. Tam

Research output: Contribution to journalReview article

6 Citations (Scopus)
28 Downloads (Pure)

Abstract

In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusion coefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies.
Original languageEnglish
Pages (from-to)143-156
Number of pages13
JournalADMET & DMPK
Volume2
Issue number3
DOIs
Publication statusPublished - 16 Sep 2014
Externally publishedYes

Fingerprint Dive into the research topics of 'Use of Voltammetry for in vitro Equilibrium and Transport Studies of Ionisable Drugs'. Together they form a unique fingerprint.

  • Cite this

    Velický, M., Rodgers, A. N. J., Dryfe, R. A. W., & Tam, K. Y. (2014). Use of Voltammetry for in vitro Equilibrium and Transport Studies of Ionisable Drugs. ADMET & DMPK, 2(3), 143-156. https://doi.org/10.5599/admet.2.3.22