Using the electroretinogram to understand how intraocular pressure elevation affects the rat retina

Bang V Bui, Zheng He, Algis J Vingrys, Christine T O Nguyen, Vickie H Y Wong, Brad Fortune

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Abstract

Intraocular pressure (IOP) elevation is a key risk factor for glaucoma. Our understanding of the effect that IOP elevation has on the eye has been greatly enhanced by the application of the electroretinogram (ERG). In this paper, we describe how the ERG in the rodent eye is affected by changes in IOP magnitude, duration, and number of spikes. We consider how the variables of blood pressure and age can modify the effect of IOP elevation on the ERG. Finally, we contrast the effects that acute and chronic IOP elevation can have on the rodent ERG.
Original languageEnglish
Article number262467
JournalJournal of Ophthalmology
Volume2013
DOIs
Publication statusPublished - 2013

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    Bui, B. V., He, Z., Vingrys, A. J., Nguyen, C. T. O., Wong, V. H. Y., & Fortune, B. (2013). Using the electroretinogram to understand how intraocular pressure elevation affects the rat retina. Journal of Ophthalmology, 2013, [262467]. https://doi.org/10.1155/2013/262467