Vaccine based on outer membrane vesicles using hydrogels as vaccine delivery system

Yadira Pastor, Isaiah Ting, Melibea Berzosa, Juan M. Irache, Carlos Gamazo*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

4 Citations (Scopus)

Abstract

A simple procedure for obtaining outer membrane vesicles from Salmonella enterica and the use of hydrogels as vaccine delivery system is described. A heat treatment in saline solution of whole bacteria rendered the release of outer membrane vesicles containing relevant antigenic components. The immunogenicity of these antigens when administered by the intranasal route may be improved after embedment into hydrogels to increase residence half-time and thus activate the mucosal immune system.

Original languageEnglish
Title of host publicationSalmonella: methods and protocols
EditorsHeide Schatten
PublisherHumana Press
Chapter14
Pages153-160
ISBN (Electronic)9781071607916
ISBN (Print)9781071607909, 9781071607930
DOIs
Publication statusPublished - 08 Sept 2020
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2182
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

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