Vaccine based on outer membrane vesicles using hydrogels as vaccine delivery system

Yadira  Pastor; Isaiah Ting; Melibea Berzosa; Juan M. Irache; Carlos  Gamazo

doi:10.1007/978-1-0716-0791-6_14

Vaccine based on outer membrane vesicles using hydrogels as vaccine delivery system

Yadira Pastor
, Isaiah Ting
, Melibea Berzosa
, Juan M. Irache
, Carlos Gamazo^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

4 Citations (Scopus)

Abstract

A simple procedure for obtaining outer membrane vesicles from Salmonella enterica and the use of hydrogels as vaccine delivery system is described. A heat treatment in saline solution of whole bacteria rendered the release of outer membrane vesicles containing relevant antigenic components. The immunogenicity of these antigens when administered by the intranasal route may be improved after embedment into hydrogels to increase residence half-time and thus activate the mucosal immune system.

Original language	English
Title of host publication	Salmonella: methods and protocols
Editors	Heide Schatten
Publisher	Humana Press
Chapter	14
Pages	153-160
ISBN (Electronic)	9781071607916
ISBN (Print)	9781071607909, 9781071607930
DOIs	https://doi.org/10.1007/978-1-0716-0791-6_14
Publication status	Published - 08 Sept 2020
Externally published	Yes

Publication series

Name	Methods in Molecular Biology
Volume	2182
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/978-1-0716-0791-6_14Licence: Unspecified

Cite this

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abstract = "A simple procedure for obtaining outer membrane vesicles from Salmonella enterica and the use of hydrogels as vaccine delivery system is described. A heat treatment in saline solution of whole bacteria rendered the release of outer membrane vesicles containing relevant antigenic components. The immunogenicity of these antigens when administered by the intranasal route may be improved after embedment into hydrogels to increase residence half-time and thus activate the mucosal immune system. ",

author = "Yadira Pastor and Isaiah Ting and Melibea Berzosa and Irache, \{Juan M.\} and Carlos Gamazo",

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Vaccine based on outer membrane vesicles using hydrogels as vaccine delivery system. / Pastor, Yadira ; Ting, Isaiah; Berzosa, Melibea et al.
Salmonella: methods and protocols. ed. / Heide Schatten. Humana Press, 2020. p. 153-160 (Methods in Molecular Biology; Vol. 2182).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

TY - CHAP

T1 - Vaccine based on outer membrane vesicles using hydrogels as vaccine delivery system

AU - Pastor, Yadira

AU - Ting, Isaiah

AU - Berzosa, Melibea

AU - Irache, Juan M.

AU - Gamazo, Carlos

PY - 2020/9/8

Y1 - 2020/9/8

N2 - A simple procedure for obtaining outer membrane vesicles from Salmonella enterica and the use of hydrogels as vaccine delivery system is described. A heat treatment in saline solution of whole bacteria rendered the release of outer membrane vesicles containing relevant antigenic components. The immunogenicity of these antigens when administered by the intranasal route may be improved after embedment into hydrogels to increase residence half-time and thus activate the mucosal immune system.

AB - A simple procedure for obtaining outer membrane vesicles from Salmonella enterica and the use of hydrogels as vaccine delivery system is described. A heat treatment in saline solution of whole bacteria rendered the release of outer membrane vesicles containing relevant antigenic components. The immunogenicity of these antigens when administered by the intranasal route may be improved after embedment into hydrogels to increase residence half-time and thus activate the mucosal immune system.

U2 - 10.1007/978-1-0716-0791-6_14

DO - 10.1007/978-1-0716-0791-6_14

M3 - Chapter (peer-reviewed)

SN - 9781071607909

SN - 9781071607930

T3 - Methods in Molecular Biology

SP - 153

EP - 160

BT - Salmonella: methods and protocols

A2 - Schatten, Heide

PB - Humana Press

ER -

Vaccine based on outer membrane vesicles using hydrogels as vaccine delivery system

Abstract

Publication series

UN SDGs

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