Vaginal formulations containing prebiotics and probiotics for treatment of bacterial vaginosis

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Abstract

Bacterial vaginosis (BV) is a common dysbiosis of the human vagina in which commensal vaginal lactobacilli are displaced by mixed pathogenic bacterial populations. Current treatments by antibiotics result in short- term cure but often lead to recurrence. Lactobacilli are being actively developed as a probiotic treatment option for BV, given their ability to inhibit growth of pathogenic microorganisms and to maintain the health and stability of the vaginal tract microbiota. Therefore, incorporation of freeze-dried lactobacillus and metronidazole (MET) into matrix-type silicone elastomer vaginal rings (VR) is a long-effective novel treatment of BV which can also prevent recurrence. Here, MED-4870 matrix-type VRs containing four different lyoprotectants of three concentrations were manufactured by reaction injection molding, and Shore M Hardness test, compression test and twist test were applied to determine the impact of incorporation of lyoprotectants on mechanical characteristics of VRs. Results indicated that incorporation of lyoprotectants can increase the resistance force and decrease the rotational angles of the VRs. As the category and concentration of incorporated lyoprotectant also have impact on the releasing profile of MET and protecting ability of lactobacillus during freeze-drying process, more research such as in-vitro release tests and microbiology tests will be needed.
Original languageEnglish
Pages (from-to)S1-S2
Number of pages2
JournalBritish Journal of Pharmacy
Volume7
Issue number2
Early online date04 Nov 2022
DOIs
Publication statusEarly online date - 04 Nov 2022

Keywords

  • Management Science and Operations Research
  • Mechanical Engineering
  • Energy Engineering and Power Technology

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