Vaginal rings for delivery of HIV microbicides

R Karl Malcolm, Susan M Fetherston, Clare F McCoy, Peter Boyd, Ian Major

Research output: Contribution to journalArticle

66 Citations (Scopus)
436 Downloads (Pure)

Abstract

Following the successful development of long-acting steroid-releasing vaginal ring devices for treatment of menopausal symptoms and contraception, there is now considerable interest in applying similar devices to the controlled release of microbicides against HIV. In this review article, the vaginal ring concept is first considered within the wider context of the early advances in controlled release technology, before describing the various types of ring device available today. The remainder of the article highlights the key developments in HIV microbicide-releasing vaginal rings, with a particular focus on the dapivirine ring that is presently in late-stage clinical testing. © 2012 Malcolm et al, publisher and licensee Dove Medical Press Ltd.
Original languageEnglish
Pages (from-to)595-605
Number of pages11
JournalInternational Journal of Women's Health
Volume2012
Issue number4
Early online date20 Nov 2012
DOIs
Publication statusPublished - 20 Nov 2012

Keywords

  • controlled release
  • sustained release
  • antiretroviral
  • dapivirine
  • SILCS diaphragm
  • silicone elastomer
  • thermoplastic

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Maternity and Midwifery

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