Abstract
Following the successful development of long-acting steroid-releasing vaginal ring devices for treatment of menopausal symptoms and contraception, there is now considerable interest in applying similar devices to the controlled release of microbicides against HIV. In this review article, the vaginal ring concept is first considered within the wider context of the early advances in controlled release technology, before describing the various types of ring device available today. The remainder of the article highlights the key developments in HIV microbicide-releasing vaginal rings, with a particular focus on the dapivirine ring that is presently in late-stage clinical testing. © 2012 Malcolm et al, publisher and licensee Dove Medical Press Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 595-605 |
| Number of pages | 11 |
| Journal | International Journal of Women's Health |
| Volume | 2012 |
| Issue number | 4 |
| Early online date | 20 Nov 2012 |
| DOIs | |
| Publication status | Published - 20 Nov 2012 |
Keywords
- controlled release
- sustained release
- antiretroviral
- dapivirine
- SILCS diaphragm
- silicone elastomer
- thermoplastic
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Oncology
- Maternity and Midwifery
Access to Document
- Vaginal rings for delivery of HIV microbicides
© 2012 Malcolm et al, publisher and licensee Dove Medical Press Ltd. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.