Vascular leak in sepsis: physiological basis and potential therapeutic advances

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Abstract

Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific pharmacological therapies are currently used to attenuate microvascular injury. Given the prominent role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies to protect the endothelium. In this review we will discuss key mechanisms and putative therapeutic agents relevant to endothelial barrier function.

Original languageEnglish
Article number97
Number of pages15
JournalCritical Care
Volume28
DOIs
Publication statusPublished - 23 Mar 2024

Keywords

  • Humans
  • Microcirculation
  • Sepsis/drug therapy
  • Endothelium
  • Endothelium, Vascular/metabolism
  • Sepsis - drug therapy
  • Endothelium, Vascular - metabolism
  • Oedema
  • Endothelial dysfunction
  • Sepsis

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