Vascular leak in sepsis: physiological basis and potential therapeutic advances

Research output: Contribution to journalReview articlepeer-review

36 Downloads (Pure)


Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific pharmacological therapies are currently used to attenuate microvascular injury. Given the prominent role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies to protect the endothelium. In this review we will discuss key mechanisms and putative therapeutic agents relevant to endothelial barrier function.

Original languageEnglish
Article number97
Number of pages15
JournalCritical Care
Publication statusPublished - 23 Mar 2024


  • Humans
  • Microcirculation
  • Sepsis/drug therapy
  • Endothelium
  • Endothelium, Vascular/metabolism
  • Sepsis - drug therapy
  • Endothelium, Vascular - metabolism
  • Oedema
  • Endothelial dysfunction
  • Sepsis


Dive into the research topics of 'Vascular leak in sepsis: physiological basis and potential therapeutic advances'. Together they form a unique fingerprint.

Cite this