Vascular leak in sepsis: physiological basis and potential therapeutic advances

Ross R. McMullan; Daniel F. McAuley; Cecilia M. O'Kane; Jonathan A. Silversides

doi:10.1186/s13054-024-04875-6

Vascular leak in sepsis: physiological basis and potential therapeutic advances

Ross R. McMullan^*, Daniel F. McAuley, Cecilia M. O'Kane, Jonathan A. Silversides

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

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Abstract

Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific pharmacological therapies are currently used to attenuate microvascular injury. Given the prominent role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies to protect the endothelium. In this review we will discuss key mechanisms and putative therapeutic agents relevant to endothelial barrier function.

Original language	English
Article number	97
Number of pages	15
Journal	Critical Care
Volume	28
DOIs	https://doi.org/10.1186/s13054-024-04875-6
Publication status	Published - 23 Mar 2024

Keywords

Humans
Microcirculation
Sepsis/drug therapy
Endothelium
Endothelium, Vascular/metabolism
Sepsis - drug therapy
Endothelium, Vascular - metabolism
Oedema
Endothelial dysfunction
Sepsis

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10.1186/s13054-024-04875-6Licence: CC BY

Vascular leak in sepsis: physiological basis and potential therapeutic advances
Copyright 2024 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.16 MBLicence: CC BY

Cite this

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title = "Vascular leak in sepsis: physiological basis and potential therapeutic advances",

abstract = "Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific pharmacological therapies are currently used to attenuate microvascular injury. Given the prominent role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies to protect the endothelium. In this review we will discuss key mechanisms and putative therapeutic agents relevant to endothelial barrier function.",

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T1 - Vascular leak in sepsis: physiological basis and potential therapeutic advances

AU - McMullan, Ross R.

AU - McAuley, Daniel F.

AU - O'Kane, Cecilia M.

AU - Silversides, Jonathan A.

PY - 2024/3/23

Y1 - 2024/3/23

N2 - Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific pharmacological therapies are currently used to attenuate microvascular injury. Given the prominent role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies to protect the endothelium. In this review we will discuss key mechanisms and putative therapeutic agents relevant to endothelial barrier function.

AB - Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific pharmacological therapies are currently used to attenuate microvascular injury. Given the prominent role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies to protect the endothelium. In this review we will discuss key mechanisms and putative therapeutic agents relevant to endothelial barrier function.

KW - Humans

KW - Microcirculation

KW - Sepsis/drug therapy

KW - Endothelium

KW - Endothelium, Vascular/metabolism

KW - Sepsis - drug therapy

KW - Endothelium, Vascular - metabolism

KW - Oedema

KW - Endothelial dysfunction

KW - Sepsis

U2 - 10.1186/s13054-024-04875-6

DO - 10.1186/s13054-024-04875-6

M3 - Review article

C2 - 38521954

SN - 1466-609X

VL - 28

JO - Critical Care

JF - Critical Care

M1 - 97

ER -

Vascular leak in sepsis: physiological basis and potential therapeutic advances

Abstract

Keywords

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