Objective To investigate international consumption patterns of child-appropriate oral formulations of antibiotics by formulation type, with a focus on dispersible tablets, using data from a global sales database. Method Antibiotic sales data for 2015 covering 74 countries and regional country groups were obtained from the MIDAS® pharmaceutical sales database, which includes samples of pharmacy wholesalers and retailers. The focus was on sales of child-appropriate oral formulations of Access antibiotics in the 2017 World Health Organization’s WHO Model list of essential medicines for children. Sales volumes are expressed using a standard unit (i.e. one tablet, capsule, ampoule or vial or 5 mL of liquid). Sales were analysed by antibiotic, WHO region and antibiotic formulation. Findings Globally, 17.7 billion standard units of child-appropriate oral antibiotic formulations were sold in 2015, representing 24% of total antibiotic sales of 74.4 billion units (both oral and parenteral) in the database. The top five child-appropriate Access antibiotics by sales volume were amoxicillin, amoxicillin with clavulanic acid, trimethoprim–sulfamethoxazole, cefalexin and ampicillin. The proportion of the top five sold for use as a syrup varied between 42% and 99%. Dispersible tablets represented only 22% of all child-appropriate oral formulation sales and made up only 15% of sales of 10 selected Access antibiotics on the model list for children. Conclusion Globally most child-appropriate oral antibiotics were not sold as dispersible tablets in 2015, as recommended by WHO. There is a clear need for novel solid forms of antibiotics suitable for use in children.
|Translated title of the contribution||Ventas mundiales de los antibióticos de uso oral para niños|
|Original language||Multiple languages|
|Number of pages||9|
|Journal||Bulletin of the World Health Organization|
|Early online date||08 May 2020|
|Publication status||Published - 01 Jul 2020|
Bibliographical noteFunding Information:
Funding: This study was sponsored by GARDP with funding from the Neth erlands Ministry of Health, Welfare and Sport.
© 2020, World Health Organization. All rights reserved.
Copyright 2020 Elsevier B.V., All rights reserved.
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health