Global sales of oral antibiotics formulated for children

Translated title of the contribution: Ventas mundiales de los antibióticos de uso oral para niños

Grace Li*, Charlotte Jackson, Julia Bielicki, Sally Ellis, Yingfen Hsia, Mike Sharland

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
34 Downloads (Pure)


Objective To investigate international consumption patterns of child-appropriate oral formulations of antibiotics by formulation type, with a focus on dispersible tablets, using data from a global sales database. Method Antibiotic sales data for 2015 covering 74 countries and regional country groups were obtained from the MIDAS® pharmaceutical sales database, which includes samples of pharmacy wholesalers and retailers. The focus was on sales of child-appropriate oral formulations of Access antibiotics in the 2017 World Health Organization’s WHO Model list of essential medicines for children. Sales volumes are expressed using a standard unit (i.e. one tablet, capsule, ampoule or vial or 5 mL of liquid). Sales were analysed by antibiotic, WHO region and antibiotic formulation. Findings Globally, 17.7 billion standard units of child-appropriate oral antibiotic formulations were sold in 2015, representing 24% of total antibiotic sales of 74.4 billion units (both oral and parenteral) in the database. The top five child-appropriate Access antibiotics by sales volume were amoxicillin, amoxicillin with clavulanic acid, trimethoprim–sulfamethoxazole, cefalexin and ampicillin. The proportion of the top five sold for use as a syrup varied between 42% and 99%. Dispersible tablets represented only 22% of all child-appropriate oral formulation sales and made up only 15% of sales of 10 selected Access antibiotics on the model list for children. Conclusion Globally most child-appropriate oral antibiotics were not sold as dispersible tablets in 2015, as recommended by WHO. There is a clear need for novel solid forms of antibiotics suitable for use in children.

Translated title of the contributionVentas mundiales de los antibióticos de uso oral para niños
Original languageMultiple languages
Pages (from-to)458-466
Number of pages9
JournalBulletin of the World Health Organization
Issue number7
Early online date08 May 2020
Publication statusPublished - 01 Jul 2020

Bibliographical note

Funding Information:
Funding: This study was sponsored by GARDP with funding from the Neth erlands Ministry of Health, Welfare and Sport.

Publisher Copyright:
© 2020, World Health Organization. All rights reserved.

Copyright 2020 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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