Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung

Thomas S Wilkinson, Andrew Conway Morris, Kallirroi Kefala, Cecilia M O'Kane, Norma R Moore, Nuala A Booth, Danny McAuley, Kevin Dhaliwal, Timothy S Walsh, Christopher Haslett, Jean-Michel Sallenave, A John Simpson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Ventilator-associated pneumonia (VAP) is characterized by neutrophils infiltrating the alveolar space. VAP is associated with high mortality, and accurate diagnosis remains difficult. We hypothesized that proteolytic enzymes from neutrophils would be significantly increased and locally produced inhibitors of human neutrophil elastase (HNE) would be decreased in BAL fluid (BALF) from patients with confirmed VAP. We postulated that in suspected VAP, neutrophil proteases in BALF may help identify "true" VAP.
Original languageEnglish
Pages (from-to)1425-32
Number of pages8
JournalChest
Volume142
Issue number6
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Bronchoalveolar Lavage Fluid
  • Case-Control Studies
  • Cell Movement
  • Diagnosis, Differential
  • Female
  • Humans
  • Lung
  • Male
  • Matrix Metalloproteinase 8
  • Matrix Metalloproteinase 9
  • Middle Aged
  • Neutrophils
  • Pancreatic Elastase
  • Peptide Hydrolases
  • Pneumonia, Ventilator-Associated
  • Tissue Inhibitor of Metalloproteinases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Wilkinson, T. S., Morris, A. C., Kefala, K., O'Kane, C. M., Moore, N. R., Booth, N. A., McAuley, D., Dhaliwal, K., Walsh, T. S., Haslett, C., Sallenave, J-M., & Simpson, A. J. (2012). Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung. Chest, 142(6), 1425-32. https://doi.org/10.1378/chest.11-3273