Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers

Marconi Rego Barros Jr; Talita Helena Araújo de Oliveira; Cristiane Moutinho Lagos de Melo; Aldo Venuti; Antonio Carlos de Freitas

doi:10.1155/2018/2912671

Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers

Marconi Rego Barros Jr, Talita Helena Araújo de Oliveira, Cristiane Moutinho Lagos de Melo, Aldo Venuti^*, Antonio Carlos de Freitas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers. This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. Both TLRs and cytokines play a central role in HPV recognition, cell maturation and differentiation as well as immune signalling. Therefore, the imbalance of this sensitive control of the immune response is a key factor for developing immunotherapies, which strengthen the host immune system to accomplish an efficient defence against HPV and HPV-infected cells. Based on this, the review is aimed at exposing the HPV immune evasion mechanisms involving TLRs and cytokines and at discussing existing and potential immunotherapeutic TLR- and cytokine-related tools.

Original language	English
Article number	2912671
Journal	Journal of Immunology Research
Volume	2018
DOIs	https://doi.org/10.1155/2018/2912671
Publication status	Published - 02 May 2018
Externally published	Yes

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10.1155/2018/2912671Licence: CC BY

Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers
Copyright 2018 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 2.27 MBLicence: CC BY

Cite this

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title = "Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers",

abstract = "The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers. This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. Both TLRs and cytokines play a central role in HPV recognition, cell maturation and differentiation as well as immune signalling. Therefore, the imbalance of this sensitive control of the immune response is a key factor for developing immunotherapies, which strengthen the host immune system to accomplish an efficient defence against HPV and HPV-infected cells. Based on this, the review is aimed at exposing the HPV immune evasion mechanisms involving TLRs and cytokines and at discussing existing and potential immunotherapeutic TLR- and cytokine-related tools.",

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AU - Venuti, Aldo

AU - de Freitas, Antonio Carlos

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AB - The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers. This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. Both TLRs and cytokines play a central role in HPV recognition, cell maturation and differentiation as well as immune signalling. Therefore, the imbalance of this sensitive control of the immune response is a key factor for developing immunotherapies, which strengthen the host immune system to accomplish an efficient defence against HPV and HPV-infected cells. Based on this, the review is aimed at exposing the HPV immune evasion mechanisms involving TLRs and cytokines and at discussing existing and potential immunotherapeutic TLR- and cytokine-related tools.

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Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers

Abstract

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