TY - JOUR
T1 - Visualising reactive oxygen species in live mammals and revealing of ROS-related system
AU - Guo, Jingke
AU - Xu, Hang
AU - Wang, Zicai
AU - Liu, Shutao
AU - Dai, You
AU - Lu, Jianzhi
AU - Zheng, Shusen
AU - Xu, Dazheng
AU - Zhou, Jianwu
AU - Ke, Lijing
AU - Cheng, Xi
AU - Xu, Mingming
AU - Zhang, Xin
AU - Guo, Yi
AU - Lin, Yingjie
AU - Ding, Wei
AU - Gao, Guanzhen
AU - Wang, Huiqin
AU - Chen, Qi
AU - Yu, Xiaowei
AU - Chen, Han
AU - Qin, Lina
AU - Sun, Xicui
AU - Li, Zhe
AU - Zheng, Shuyu
AU - Wang, Jiaqi
AU - Cheng, Yanglei
AU - Qiu, Shuai
AU - Hu, Yuqiu
AU - Huang, Penghan
AU - Lin, Chuntong
AU - Wu, Qiming
AU - Li, Yubo
AU - Chen, Tianbao
AU - Shaw, Chris
AU - Ho, Sherry
AU - Wang, Qiang
AU - Gu, Huaiyu
AU - Rao, Pingfan
PY - 2019/10/21
Y1 - 2019/10/21
N2 - Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS) indicators, the connective tissues of dura mater, facial fascia, pericardium, linea alba, dorsa fascia and other body parts, emitted specific and intense fluorescent signals. Moreover, the fluorescent signals along the linea alba of SD rats, did not result from the local presence of ROS but from the interaction of ROS indicators with electrons flowing through this tissue. Furthermore, the electrons travelling along the linea alba of mice were revealed to originate from mitochondria. These data suggest that mitochondrial-leaked electrons may be transported extracellularly to a hitherto undescribed system of connective tissues, which is pervasively networked, electrically conductive and metabolically related.
AB - Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS) indicators, the connective tissues of dura mater, facial fascia, pericardium, linea alba, dorsa fascia and other body parts, emitted specific and intense fluorescent signals. Moreover, the fluorescent signals along the linea alba of SD rats, did not result from the local presence of ROS but from the interaction of ROS indicators with electrons flowing through this tissue. Furthermore, the electrons travelling along the linea alba of mice were revealed to originate from mitochondria. These data suggest that mitochondrial-leaked electrons may be transported extracellularly to a hitherto undescribed system of connective tissues, which is pervasively networked, electrically conductive and metabolically related.
KW - Connective tissue, cynomolgus monkey, electron, mitochondria, reactive oxygen species
U2 - 10.1080/10715762.2019.1677902
DO - 10.1080/10715762.2019.1677902
M3 - Article
SN - 1071-5762
JO - Free Radical Research
JF - Free Radical Research
ER -