Visualising reactive oxygen species in live mammals and revealing of ROS-related system

Jingke Guo, Hang Xu, Zicai Wang, Shutao Liu, You Dai, Jianzhi Lu, Shusen Zheng, Dazheng Xu, Jianwu Zhou, Lijing Ke, Xi Cheng, Mingming Xu, Xin Zhang, Yi Guo, Yingjie Lin, Wei Ding, Guanzhen Gao, Huiqin Wang, Qi Chen, Xiaowei YuHan Chen, Lina Qin, Xicui Sun, Zhe Li, Shuyu Zheng, Jiaqi Wang, Yanglei Cheng, Shuai Qiu, Yuqiu Hu, Penghan Huang, Chuntong Lin, Qiming Wu, Yubo Li, Tianbao Chen, Chris Shaw, Sherry Ho, Qiang Wang, Huaiyu Gu, Pingfan Rao

Research output: Contribution to journalArticle

Abstract

Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS) indicators, the connective tissues of dura mater, facial fascia, pericardium, linea alba, dorsa fascia and other body parts, emitted specific and intense fluorescent signals. Moreover, the fluorescent signals along the linea alba of SD rats, did not result from the local presence of ROS but from the interaction of ROS indicators with electrons flowing through this tissue. Furthermore, the electrons travelling along the linea alba of mice were revealed to originate from mitochondria. These data suggest that mitochondrial-leaked electrons may be transported extracellularly to a hitherto undescribed system of connective tissues, which is pervasively networked, electrically conductive and metabolically related.
Original languageEnglish
Number of pages11
JournalFree Radical Research
DOIs
Publication statusPublished - 21 Oct 2019

Keywords

  • Connective tissue, cynomolgus monkey, electron, mitochondria, reactive oxygen species

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  • Cite this

    Guo, J., Xu, H., Wang, Z., Liu, S., Dai, Y., Lu, J., Zheng, S., Xu, D., Zhou, J., Ke, L., Cheng, X., Xu, M., Zhang, X., Guo, Y., Lin, Y., Ding, W., Gao, G., Wang, H., Chen, Q., ... Rao, P. (2019). Visualising reactive oxygen species in live mammals and revealing of ROS-related system. Free Radical Research. https://doi.org/10.1080/10715762.2019.1677902