Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3)

A. M. Mondul, I. M. Shui, S. J. Weinstein, K. K. Tsilidis, A. D. Joshi, A. Agudo, C. D. Berg, J. E. Buring, D. I. Chasman, M. M. Gaudet, C. Haiman, S. E. Hankinson, R. N. Hoover, K. T. Khaw, T. Kuhn, M. Kvaskoff, L. Le Marchand, S. Lindstrom, K. Overvad, P. H. PeetersE. Riboli, P. M. Ridker, D. O. Stram, M. Sund, D. Trichopoulos, R. Tumino, E. Weiderpass, W. Willett, P. Kraft, R. G. Ziegler, D. Albanes

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH)D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.

Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25(OH)D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.

Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.

Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH)D–related genotypes, and breast cancer risk.
Original languageEnglish
Pages (from-to)627-30
JournalCancer Epidemiology Biomarkers & Prevention
Volume24
Issue number3
DOIs
Publication statusPublished - 26 Dec 2014

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