Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3)

A. M. Mondul; I. M. Shui; S. J. Weinstein; K. K. Tsilidis; A. D. Joshi; A. Agudo; C. D. Berg; J. E. Buring; D. I. Chasman; M. M. Gaudet; C. Haiman; S. E. Hankinson; R. N. Hoover; K. T. Khaw; T. Kuhn; M. Kvaskoff; L. Le Marchand; S. Lindstrom; K. Overvad; P. H. Peeters; E. Riboli; P. M. Ridker; D. O. Stram; M. Sund; D. Trichopoulos; R. Tumino; E. Weiderpass; W. Willett; P. Kraft; R. G. Ziegler; D. Albanes

doi:10.1158/1055-9965.Epi-14-1127

Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3)

A. M. Mondul, I. M. Shui, S. J. Weinstein, K. K. Tsilidis, A. D. Joshi, A. Agudo, C. D. Berg, J. E. Buring, D. I. Chasman, M. M. Gaudet, C. Haiman, S. E. Hankinson, R. N. Hoover, K. T. Khaw, T. Kuhn, M. Kvaskoff, L. Le Marchand, S. Lindstrom, K. Overvad, P. H. PeetersE. Riboli, P. M. Ridker, D. O. Stram, M. Sund, D. Trichopoulos, R. Tumino, E. Weiderpass, W. Willett, P. Kraft, R. G. Ziegler, D. Albanes

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH)D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.

Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25(OH)D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.

Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.

Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH)D–related genotypes, and breast cancer risk.

Original language	English
Pages (from-to)	627-30
Journal	Cancer Epidemiology Biomarkers & Prevention
Volume	24
Issue number	3
DOIs	https://doi.org/10.1158/1055-9965.Epi-14-1127
Publication status	Published - 26 Dec 2014

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Mondul, A. M., Shui, I. M., Weinstein, S. J., Tsilidis, K. K., Joshi, A. D., Agudo, A., Berg, C. D., Buring, J. E., Chasman, D. I., Gaudet, M. M., Haiman, C., Hankinson, S. E., Hoover, R. N., Khaw, K. T., Kuhn, T., Kvaskoff, M., Le Marchand, L., Lindstrom, S., Overvad, K., ... Albanes, D. (2014). Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3). Cancer Epidemiology Biomarkers & Prevention, 24(3), 627-30. https://doi.org/10.1158/1055-9965.Epi-14-1127

@article{ae5d7db7f40f4f5cbf999e243b805589,

title = "Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3)",

abstract = "Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH)D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25(OH)D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH)D–related genotypes, and breast cancer risk.",

author = "Mondul, {A. M.} and Shui, {I. M.} and Weinstein, {S. J.} and Tsilidis, {K. K.} and Joshi, {A. D.} and A. Agudo and Berg, {C. D.} and Buring, {J. E.} and Chasman, {D. I.} and Gaudet, {M. M.} and C. Haiman and Hankinson, {S. E.} and Hoover, {R. N.} and Khaw, {K. T.} and T. Kuhn and M. Kvaskoff and {Le Marchand}, L. and S. Lindstrom and K. Overvad and Peeters, {P. H.} and E. Riboli and Ridker, {P. M.} and Stram, {D. O.} and M. Sund and D. Trichopoulos and R. Tumino and E. Weiderpass and W. Willett and P. Kraft and Ziegler, {R. G.} and D. Albanes",

year = "2014",

month = dec,

day = "26",

doi = "10.1158/1055-9965.Epi-14-1127",

language = "English",

volume = "24",

pages = "627--30",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1055-9965",

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Mondul, AM, Shui, IM, Weinstein, SJ, Tsilidis, KK, Joshi, AD, Agudo, A, Berg, CD, Buring, JE, Chasman, DI, Gaudet, MM, Haiman, C, Hankinson, SE, Hoover, RN, Khaw, KT, Kuhn, T, Kvaskoff, M, Le Marchand, L, Lindstrom, S, Overvad, K, Peeters, PH, Riboli, E, Ridker, PM, Stram, DO, Sund, M, Trichopoulos, D, Tumino, R, Weiderpass, E, Willett, W, Kraft, P, Ziegler, RG & Albanes, D 2014, 'Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3)', Cancer Epidemiology Biomarkers & Prevention, vol. 24, no. 3, pp. 627-30. https://doi.org/10.1158/1055-9965.Epi-14-1127

TY - JOUR

T1 - Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3)

AU - Mondul, A. M.

AU - Shui, I. M.

AU - Weinstein, S. J.

AU - Tsilidis, K. K.

AU - Joshi, A. D.

AU - Agudo, A.

AU - Berg, C. D.

AU - Buring, J. E.

AU - Chasman, D. I.

AU - Gaudet, M. M.

AU - Haiman, C.

AU - Hankinson, S. E.

AU - Hoover, R. N.

AU - Khaw, K. T.

AU - Kuhn, T.

AU - Kvaskoff, M.

AU - Le Marchand, L.

AU - Lindstrom, S.

AU - Overvad, K.

AU - Peeters, P. H.

AU - Riboli, E.

AU - Ridker, P. M.

AU - Stram, D. O.

AU - Sund, M.

AU - Trichopoulos, D.

AU - Tumino, R.

AU - Weiderpass, E.

AU - Willett, W.

AU - Kraft, P.

AU - Ziegler, R. G.

AU - Albanes, D.

PY - 2014/12/26

Y1 - 2014/12/26

N2 - Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH)D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25(OH)D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH)D–related genotypes, and breast cancer risk.

AB - Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH)D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25(OH)D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH)D–related genotypes, and breast cancer risk.

U2 - 10.1158/1055-9965.Epi-14-1127

DO - 10.1158/1055-9965.Epi-14-1127

M3 - Article

SN - 1055-9965

VL - 24

SP - 627

EP - 630

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

IS - 3

ER -

Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3)

Abstract

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