Weak organic acid synergy towards the prevention of catheter blockages

Jane Burns; Colin McCoy; Nicola Irwin

doi:10.1016/j.jhin.2021.01.025

Weak organic acid synergy towards the prevention of catheter blockages

Jane Burns
, Colin McCoy
, Nicola Irwin^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

263 Downloads (Pure)

Abstract

Background: Up to 50% of all long-term catheterized individuals experience recurrent episodes of urinary catheter infections and blockages, leading to urine retention, pyelonephritis and septicaemia if the catheter is left in situ. We have previously reported the synergistic activity of weak organic acid (WOA) combinations against nosocomial uropathogens.
Aim: To investigate the efficacy of selected WOAs, citric acid and propionic acid, alone and in combination, on prevention of crystalline biofilm formation and catheter blockages.
Methods: Static crystallization assays and dynamic in vitro bladder model assays, with scanning electron microscopy, were performed for determination of bacterial viability, urinary pH and time to catheter blockage.
Findings: The rate of encrustation around the catheter eyeholes was reduced in the presence of the citric acid/propionic acid combination, extending the time to blockage three-fold.
Conclusion: Synergistic WOA combinations identified herein represent promising alternatives to antibiotics to combat the global healthcare burden of catheter-associated urinary tract infections and related blockages.

Original language	English
Pages (from-to)	69-77
Number of pages	9
Journal	Journal of Hospital Infection
Volume	111
Early online date	02 Feb 2021
DOIs	https://doi.org/10.1016/j.jhin.2021.01.025
Publication status	Published - 01 May 2021

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10.1016/j.jhin.2021.01.025Licence: Unspecified

Weak organic acid synergy towards the prevention of catheter blockages
Copyright 2021 Elsevier Ltd. This manuscript is distributed under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Accepted author manuscript, 1.32 MBLicence: Unspecified

Combatting device-associated, healthcare-associated infections with innovative anti-biofouling and anti-blocking technologies
Burns, J. (Author), McCoy, C. (Supervisor) & Carson, L. (Supervisor), Jul 2023
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

@article{725cf6a1d4a5455fa2c5b60d46756574,

title = "Weak organic acid synergy towards the prevention of catheter blockages",

abstract = "Background: Up to 50\% of all long-term catheterized individuals experience recurrent episodes of urinary catheter infections and blockages, leading to urine retention, pyelonephritis and septicaemia if the catheter is left in situ. We have previously reported the synergistic activity of weak organic acid (WOA) combinations against nosocomial uropathogens. Aim: To investigate the efficacy of selected WOAs, citric acid and propionic acid, alone and in combination, on prevention of crystalline biofilm formation and catheter blockages. Methods: Static crystallization assays and dynamic in vitro bladder model assays, with scanning electron microscopy, were performed for determination of bacterial viability, urinary pH and time to catheter blockage. Findings: The rate of encrustation around the catheter eyeholes was reduced in the presence of the citric acid/propionic acid combination, extending the time to blockage three-fold. Conclusion: Synergistic WOA combinations identified herein represent promising alternatives to antibiotics to combat the global healthcare burden of catheter-associated urinary tract infections and related blockages. ",

author = "Jane Burns and Colin McCoy and Nicola Irwin",

year = "2021",

month = may,

day = "1",

doi = "10.1016/j.jhin.2021.01.025",

language = "English",

volume = "111",

pages = "69--77",

journal = "Journal of Hospital Infection",

issn = "0195-6701",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Weak organic acid synergy towards the prevention of catheter blockages

AU - Burns, Jane

AU - McCoy, Colin

AU - Irwin, Nicola

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Background: Up to 50% of all long-term catheterized individuals experience recurrent episodes of urinary catheter infections and blockages, leading to urine retention, pyelonephritis and septicaemia if the catheter is left in situ. We have previously reported the synergistic activity of weak organic acid (WOA) combinations against nosocomial uropathogens. Aim: To investigate the efficacy of selected WOAs, citric acid and propionic acid, alone and in combination, on prevention of crystalline biofilm formation and catheter blockages. Methods: Static crystallization assays and dynamic in vitro bladder model assays, with scanning electron microscopy, were performed for determination of bacterial viability, urinary pH and time to catheter blockage. Findings: The rate of encrustation around the catheter eyeholes was reduced in the presence of the citric acid/propionic acid combination, extending the time to blockage three-fold. Conclusion: Synergistic WOA combinations identified herein represent promising alternatives to antibiotics to combat the global healthcare burden of catheter-associated urinary tract infections and related blockages.

AB - Background: Up to 50% of all long-term catheterized individuals experience recurrent episodes of urinary catheter infections and blockages, leading to urine retention, pyelonephritis and septicaemia if the catheter is left in situ. We have previously reported the synergistic activity of weak organic acid (WOA) combinations against nosocomial uropathogens. Aim: To investigate the efficacy of selected WOAs, citric acid and propionic acid, alone and in combination, on prevention of crystalline biofilm formation and catheter blockages. Methods: Static crystallization assays and dynamic in vitro bladder model assays, with scanning electron microscopy, were performed for determination of bacterial viability, urinary pH and time to catheter blockage. Findings: The rate of encrustation around the catheter eyeholes was reduced in the presence of the citric acid/propionic acid combination, extending the time to blockage three-fold. Conclusion: Synergistic WOA combinations identified herein represent promising alternatives to antibiotics to combat the global healthcare burden of catheter-associated urinary tract infections and related blockages.

U2 - 10.1016/j.jhin.2021.01.025

DO - 10.1016/j.jhin.2021.01.025

M3 - Article

SN - 0195-6701

VL - 111

SP - 69

EP - 77

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

ER -

Weak organic acid synergy towards the prevention of catheter blockages

Abstract

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Student theses

Combatting device-associated, healthcare-associated infections with innovative anti-biofouling and anti-blocking technologies

Cite this