What are RBC-transfusion-dependence and -independence?

R P Gale, G Barosi, T Barbui, F Cervantes, K Dohner, B Dupriez, V Gupta, C Harrison, R Hoffman, J-J Kiladjian, R Mesa, M F Mc Mullin, F Passamonti, V Ribrag, G Roboz, G Saglio, A Vannucchi, S Verstovsek, Mary Frances McMullin

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)


The term RBC-transfusion-dependence is widely-used by hematologists to describe a condition of severe anemia typically arising when erythropoiesis is reduced such that a person continuously requires =1 RBC-transfusions over a specified interval. Defining a person as RBC-transfusion-dependent has important implications in diverse hematological disorders especially because it strongly-correlated with decreased survival. Conversely, becoming RBC-transfusion-independent or receiving fewer RBC-transfusions over a specified interval is defined as improvement or response in many disease- and/or therapy-setting. Whether this correlates with improved survival is controversial. We used a structured expert-panel consensus panel process to define RBC-transfusion-dependence and -independence or improvement. We suggest these definitions may prove useful to persons studying or treating these diseases.
Original languageEnglish
Pages (from-to)8-11
Number of pages4
JournalLeukemia research
Issue number1
Publication statusPublished - Jan 2011

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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