When the guardian becomes the enemy, targeting ATM in PTEN deficient cancers

Nuala McCabe, Stephen M. Walker, Richard D. Kennedy

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Ataxia Telangiectasia Mutated (ATM) is an important signalling molecule in the DNA damage response and inhibitors of ATM are under clinical development. We identified a synthetic lethal interaction between ATM inhibition and Phosphatase and tensin homolog (PTEN) loss which was the result of increased oxidative stress. Inhibition of ATM therefore represents a novel strategy to target PTEN associated cancers.
Original languageEnglish
Article numbere1053595
Number of pages3
JournalMolecular & Cellular Oncology
Volume3
Issue number1
Early online date10 Jun 2015
DOIs
Publication statusPublished - 2016

Keywords

  • PTEN Phosphohydrolase
  • Ataxia Telangiectasia Mutated Proteins
  • Prostate cancer

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