Whey proteins have beneficial effects on intestinal enteroendocrine cells stimulating cell growth and increasing the production and secretion of incretin hormones

Anna L. Gillespie*, Danielle Calderwood, Laura Hobson, Brian D. Green

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Whey protein has been indicated to curb diet-induced obesity, glucose intolerance and delay the onset of type 2 diabetes mellitus. Here the effects of intact crude whey, intact individual whey proteins and beta-lactoglobulin hydrolysates on an enteroendocrine (EE) cell model were examined. STC-1 pGIP/neo cells were incubated with several concentrations of yogurt whey (YW), cheese whey (CW), beta-lactoglobulin (BLG), alpha-lactalbumin (ALA) and bovine serum albumin (BSA). The findings demonstrate that BLG stimulates EE cell proliferation, and also GLP-1 secretion (an effect which is lost following hydrolysis with chymotrypsin or trypsin). ALA is a highly potent GLP-1 secretagogue which also increases the intracellular levels of GLP-1. Conversely, whey proteins and hydrolysates had little impact on GIP secretion. This appears to be the first investigation of the effects of the three major proteins of YW and CW on EE cells. The anti-diabetic potential of whey proteins should be further investigated.

Original languageEnglish
Pages (from-to)120-128
Number of pages9
JournalFood Chemistry
Volume189
Early online date18 Feb 2015
DOIs
Publication statusPublished - 15 Dec 2015
EventASSET 2014: Food Integrity and Traceability Conference - Queen's University Belfast, Belfast, United Kingdom
Duration: 08 Apr 201410 Apr 2014

Keywords

  • Diabetes
  • GIP
  • GLP-1
  • Incretin hormones
  • PGIP/Neo STC-1
  • Protein
  • Whey

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

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