Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium

Harald Oey, Martha Zakrzewski, Kerstin Gravermann, Neil D Young, Pasi K Korhonen, Geoffrey N Gobert, Sujeevi Nawaratna, Shihab Hasan, David M Martínez, Hong You, Martin Lavin, Malcolm K Jones, Mark A Ragan, Jens Stoye, Ana Oleaga, Aidan M Emery, Bonnie Webster, David Rollinson, Robin B Gasser, Donald P McManusLutz Krause

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Intestinal infection by the parasitic blood fluke Schistosoma bovis is a common veterinary problem in Africa and the Middle East and occasionally in the Mediterranean Region. The species also has the ability to form interspecific hybrids with the human parasite S. haematobium with natural hybridisation observed in West Africa, presenting possible zoonotic transmission. Additionally, this exchange of alleles between species may dramatically influence disease dynamics and parasite evolution. We have generated a 374 Mb assembly of the S. bovis genome using Illumina and PacBio-based technologies. Despite infecting different hosts and organs, the genome sequences of S. bovis and S. haematobium appeared strikingly similar with 97% sequence identity. The two species share 98% of protein-coding genes, with an average sequence identity of 97.3% at the amino acid level. Genome comparison identified large continuous parts of the genome (up to several 100 kb) showing almost 100% sequence identity between S. bovis and S. haematobium. It is unlikely that this is a result of genome conservation and provides further evidence of natural interspecific hybridization between S. bovis and S. haematobium. Our results suggest that foreign DNA obtained by interspecific hybridization was maintained in the population through multiple meiosis cycles and that hybrids were sexually reproductive, producing viable offspring. The S. bovis genome assembly forms a highly valuable resource for studying schistosome evolution and exploring genetic regions that are associated with species-specific phenotypic traits.

Original languageEnglish
Article numbere1007513
JournalPLoS Pathogens
Volume15
Issue number1
Early online date23 Jan 2019
DOIs
Publication statusEarly online date - 23 Jan 2019
Externally publishedYes

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