WS18.4 Intestinal current measurement as outcome marker for clinical trials: the ECFS CTN certification process and central reading core facility

H. de Jonge; Inez Bronsveld; Paola Melotti; Silke van Koningsbruggen-Rietschel; Isabelle Sermet-Gaudelus; Kate Hayes; N Derichs

doi:10.1016/S1569-1993(16)30166-7

WS18.4 Intestinal current measurement as outcome marker for clinical trials: the ECFS CTN certification process and central reading core facility

H. de Jonge, Inez Bronsveld, Paola Melotti, Silke van Koningsbruggen-Rietschel, Isabelle Sermet-Gaudelus, Kate Hayes, N Derichs

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to conference › Abstract › peer-review

Abstract

Multiple CFTR modulators are under development for
mutation-specific CF therapy. CFTR biomarkers play an important role
for the effect evaluation in clinical trials. Intestinal current measurement
(ICM), precisely determining ex vivo CFTR function in human rectal
biopsies, has been standardized in an ECFS ICM SOP prepared by
the ECFS Diagnostic Network Working Group and ECFS Clinical Trials
Network (CTN) standardisation committee.

Original language	English
Pages	S30
DOIs	https://doi.org/10.1016/S1569-1993(16)30166-7
Publication status	Published - 2016

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title = "WS18.4 Intestinal current measurement as outcome marker for clinical trials: the ECFS CTN certification process and central reading core facility",

abstract = "Multiple CFTR modulators are under development formutation-specific CF therapy. CFTR biomarkers play an important rolefor the effect evaluation in clinical trials. Intestinal current measurement(ICM), precisely determining ex vivo CFTR function in human rectalbiopsies, has been standardized in an ECFS ICM SOP prepared bythe ECFS Diagnostic Network Working Group and ECFS Clinical TrialsNetwork (CTN) standardisation committee.",

author = "{de Jonge}, H. and Inez Bronsveld and Paola Melotti and {van Koningsbruggen-Rietschel}, Silke and Isabelle Sermet-Gaudelus and Kate Hayes and N Derichs",

year = "2016",

doi = "10.1016/S1569-1993(16)30166-7",

language = "English",

pages = "S30",

}

TY - CONF

T1 - WS18.4 Intestinal current measurement as outcome marker for clinical trials: the ECFS CTN certification process and central reading core facility

AU - de Jonge, H.

AU - Bronsveld, Inez

AU - Melotti, Paola

AU - van Koningsbruggen-Rietschel, Silke

AU - Sermet-Gaudelus, Isabelle

AU - Hayes, Kate

AU - Derichs, N

PY - 2016

Y1 - 2016

N2 - Multiple CFTR modulators are under development formutation-specific CF therapy. CFTR biomarkers play an important rolefor the effect evaluation in clinical trials. Intestinal current measurement(ICM), precisely determining ex vivo CFTR function in human rectalbiopsies, has been standardized in an ECFS ICM SOP prepared bythe ECFS Diagnostic Network Working Group and ECFS Clinical TrialsNetwork (CTN) standardisation committee.

AB - Multiple CFTR modulators are under development formutation-specific CF therapy. CFTR biomarkers play an important rolefor the effect evaluation in clinical trials. Intestinal current measurement(ICM), precisely determining ex vivo CFTR function in human rectalbiopsies, has been standardized in an ECFS ICM SOP prepared bythe ECFS Diagnostic Network Working Group and ECFS Clinical TrialsNetwork (CTN) standardisation committee.

U2 - 10.1016/S1569-1993(16)30166-7

DO - 10.1016/S1569-1993(16)30166-7

M3 - Abstract

SP - S30

ER -

WS18.4 Intestinal current measurement as outcome marker for clinical trials: the ECFS CTN certification process and central reading core facility

Abstract

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