Zinc-Catalyzed Borylation of Primary, Secondary and Tertiary Alkyl Halides with Alkoxy Diboron Reagents at Room Temperature

Dr Shubhankar Kumar Bose, Dr. Katharina Fucke, Prof. Dr. Lei Liu, Prof. Dr. Patrick G. Steel, Prof. Dr. Todd B. Marder

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

A new catalytic system based on a ZnII NHC precursor has been developed for the cross-coupling reaction of alkyl halides with diboron reagents, which represents a novel use of a Group XII catalyst for C-X borylation. This approach gives borylations of unactivated primary, secondary, and tertiary alkyl halides at room temperature to furnish alkyl boronates, with good functional-group compatibility, under mild conditions. Preliminary mechanistic investigations demonstrated that this borylation reaction seems to involve one-electron processes.
Original languageEnglish
Pages (from-to)1799-1803
JournalAngewandte Chemie International Edition
Volume53
Early online date13 Jan 2014
DOIs
Publication statusPublished - 10 Feb 2014

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