TY - JOUR
T1 - Zinc-Catalyzed Borylation of Primary, Secondary and Tertiary Alkyl Halides with Alkoxy Diboron Reagents at Room Temperature
AU - Bose, Dr Shubhankar Kumar
AU - Fucke, Dr. Katharina
AU - Liu, Prof. Dr. Lei
AU - Steel, Prof. Dr. Patrick G.
AU - Marder, Prof. Dr. Todd B.
PY - 2014/2/10
Y1 - 2014/2/10
N2 - A new catalytic system based on a ZnII NHC precursor has been developed for the cross-coupling reaction of alkyl halides with diboron reagents, which represents a novel use of a Group XII catalyst for C-X borylation. This approach gives borylations of unactivated primary, secondary, and tertiary alkyl halides at room temperature to furnish alkyl boronates, with good functional-group compatibility, under mild conditions. Preliminary mechanistic investigations demonstrated that this borylation reaction seems to involve one-electron processes.
AB - A new catalytic system based on a ZnII NHC precursor has been developed for the cross-coupling reaction of alkyl halides with diboron reagents, which represents a novel use of a Group XII catalyst for C-X borylation. This approach gives borylations of unactivated primary, secondary, and tertiary alkyl halides at room temperature to furnish alkyl boronates, with good functional-group compatibility, under mild conditions. Preliminary mechanistic investigations demonstrated that this borylation reaction seems to involve one-electron processes.
U2 - 10.1002/anie.201308855
DO - 10.1002/anie.201308855
M3 - Article
SN - 1433-7851
VL - 53
SP - 1799
EP - 1803
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
ER -