Augmenting radiation sensitivity of HPV-negative head and neck cancer through mannose intervention

  • Tongchuan Wang

Student thesis: Doctoral Thesis › Doctor of Philosophy

Abstract

This work demonstrates that mannose has the ability to sensitise HPV (-) HNSCC to radiation under normoxic and hypoxic conditions by ATP-dependent DNA damage repair and inhibiting HIF-1a. The metabolic profile of irradiated HNSCC cells further indicates that mannose interferes wit multiple metabolic pathways in the absence of functional phosphomannose isomerse (PMI). These findings highlight the potential of targeting PMI as an effective therapeutic target in combination with mannose-adjuvanted radiotherapy regimens. 

Thesis is embargoed until 31 July 2029.
Date of AwardJul 2024
Original languageEnglish
Awarding Institution
  • Queen's University Belfast
SupervisorJonathan Coulter (Supervisor) & Karl Butterworth (Supervisor)

Keywords

  • Radiotherapy
  • tumour metabolism
  • mannose
  • PMI
  • gold nanoparticles
  • Hypoxia

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