Characterising pathways driving aggressive biology and chemoresistance in triple negative breast cancers biology and chemoresistance in triple negative breast cancers

  • Charlotte McBrien

Student thesis: Doctoral ThesisDoctor of Philosophy


This body of work served to investigate the mechanisms driving chemoresistance in a series of in vitro TNBC cell line models. Molecular characterisation and comparison of drug resistant models allowed for the identification of promising druggable targets, whose efficacy in restoring chemosensitivity was assessed via a number of methods, including RNAi, CRISPR, and targeted inhibition. In all, the preliminary identification of a means to sensitise an otherwise highly aggressive cancer to chemotherapeutics, represents an essential step in order to improve current standard of care practices of an otherwise intractable disease.

Date of AwardJul 2022
Original languageEnglish
Awarding Institution
  • Queen's University Belfast
SponsorsNorthern Ireland Department for the Economy
SupervisorNiamh Buckley (Supervisor) & Paul Mullan (Supervisor)


  • Oncology
  • breast cancer
  • chemoresistance
  • triple negative breast cancer
  • CDKN1A
  • ABCB1
  • TP63
  • molecular biology
  • cell signalling
  • RNAi
  • drug resistance
  • chemotherapy

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