Continuous flow as an enabling technology for API synthesis through reactive intermediates

  • Lara Nolan

Student thesis: Doctoral Thesis › Doctor of Philosophy

Abstract

This thesis details the implementation of continuous flow chemistry as a safe and scalable method for the development of chemical processes employing organometallic substrates and heterogeneous catalysts. The chemical transformations studied have applications in the synthesis of active pharmaceutical ingredients and it is hoped that the methods developed herein will aid in the continuous manufacture of such commodities.

Thesis embargoed until 31 December 2026.
Date of AwardDec 2024
Original languageEnglish
Awarding Institution
  • Queen's University Belfast
SponsorsEU Horizon 2020 Marie Sklodowska-Curie ITN Programme
SupervisorPeter Knipe (Supervisor), Paul Dingwall (Supervisor) & Mark Muldoon (Supervisor)

Keywords

  • Continuous flow
  • organic chemistry
  • reactive intermediates

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