Eutectic systems embedded within implantable matrices for improved postsurgical wound management and recovery

Abstract

Therapeutic deep eutectic solvents (THEDES) are emerging drug-enabling systems that offer improved stability and biopharmaceutical performance over conventional amorphous formulations. This thesis systematically investigate
THEDES from fundamental principles to clinical translation for post-surgical drug delivery.
Mechanistic studies elucidated the role of hydrogen bonding, glass-forming ability, and composition in THEDES formation and stability, while revealing a thermodynamically preferred "THEDES point." Polymer compatibility was examined leading to practical formulation guidelines and a novel thermal quantification method. These insights enabled successful incorporation of THEDES into implantable polymeric matrices with tunable mechanical and release properties. A biorelevant simulated peritoneal fluid was also developed to enhance in vitro-in vivo correlation.

Thesis embargoed until 31st July 2031

Date of Award	Jul 2026
Original language	English
Awarding Institution	Queen's University Belfast
Sponsors	the Ministry of Higher Education of the Arab Republic of Egypt
Supervisor	David Jones (Supervisor), Shu Li (Supervisor) & Gavin Andrews (Supervisor)