Identification and activity assessment of a bioactive peptide QUB-1460 from the skinsecretion of the Northeast Forest Frog (Rana dybowskii)

  • Qiangwei Li

Student thesis: Masters Thesis › Master of Philosophy

Abstract

Antibiotic resistance, leading to increased treatment failures and substantial economic burdens, poses a significant threat to modern medicine's advancement. Antimicrobial peptides (AMPs), because of their primary action mechanism of disrupting bacterial membrane integrity, offer a promising solution to counteract the limitations of conventional antibiotics due to a reduced potential for resistance induction. AMPs, especially positively-charged, alpha-helical, amphipathic polypeptides found in amphibian skin secretions, have various physiological and pharmacological activities. This research led to the discovery of an antimicrobial peptide, QUB-1460, in the skin secretions of Rana dybowskii.

Thesis embargoed until 31st December 2028
Date of AwardDec 2023
Original languageEnglish
Awarding Institution
  • Queen's University Belfast
SupervisorLei Wang (Supervisor) & Tianbao Chen (Supervisor)

Keywords

  • Antimicrobial peptides
  • immune system
  • bacteria
  • Cytotoxicity
  • natural products

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