Identification and bioactivity study of a naturally-occurring peptide, Brevinin-2LK, from the skin secretion of the frog, Limnonectes kuhlii

Student thesis: Masters Thesis › Master of Philosophy

Abstract

Antimicrobial peptides (AMPs) derived from amphibian sources have been extensively studied and utilized as models for investigating the mechanisms and potential applications of peptide-based anti-infectious medications. In this work, using the technology of ‘shotgun’ cloning, an AMP was identified and characterised from Limnonectes kuhlii skin secretion and named Brevinin-2LK. The functional selectivity of Brevinin-2LK (LK) was investigated by using in vitro assays, including antibacterial, haemolytic, and anticancer tests.

Thesis is embargoed until 31 December 2028.
Date of AwardDec 2023
Original languageEnglish
Awarding Institution
  • Queen's University Belfast
SupervisorMei Zhou (Supervisor) & Tianbao Chen (Supervisor)

Keywords

  • antimicrobial peptide
  • biological activity

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