The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. Increased molecular understanding of this heterogeneous disease is needed to overcome resistance to chemotherapy and develop novel therapeutic strategies. This study uses gene expression data to perform unbiased molecular subtyping followed by functional genomic screening to identify novel drug targets to improve outcomes in OAC.
Identification of targetable mediators of resistance to chemotherapy in oesophageal adenocarcinoma
Douglas, R. (Author). Jul 2021
Student thesis: Doctoral Thesis › Doctor of Philosophy