Identification of targetable mediators of resistance to chemotherapy in oesophageal adenocarcinoma

  • Rosalie Douglas

Student thesis: Doctoral ThesisDoctor of Philosophy

Abstract

The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. Increased molecular understanding of this heterogeneous disease is needed to overcome resistance to chemotherapy and develop novel therapeutic strategies. This study uses gene expression data to perform unbiased molecular subtyping followed by functional genomic screening to identify novel drug targets to improve outcomes in OAC.
Date of AwardJul 2021
Original languageEnglish
Awarding Institution
  • Queen's University Belfast
SupervisorRichard Turkington (Supervisor) & Richard Kennedy (Supervisor)

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