Abstract
An extremely large volume of new chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. The synthesis of multi-component pharmaceutical systems, including the lesser-studied eutectic and liquid systems, pose as approaches with which to improve the physicochemical properties of these APIs. Currently, one of the biggest development hurdles associated with multi-component systems, and in particular liquid systems, is their intermediate handling. Consequently, this research aims to use a continuous manufacturing technique, hot-melt extrusion (HME), to manufacture multi-component systems while removing their intermediate handling.Thesis embargoed until 31 December 2026.
| Date of Award | Dec 2021 |
|---|---|
| Original language | English |
| Awarding Institution |
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| Sponsors | Northern Ireland Department for the Economy |
| Supervisor | Gavin Andrews (Supervisor) & Shu Li (Supervisor) |
Keywords
- Mechanochemistry
- hot-melt extrusion
- eutectic
- multi-component pharmaceutical materials
- therapeutic deep eutectic
- salt
- reactive extrusion
- multivariate analysis