AbstractAn extremely large volume of new chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. The synthesis of multi-component pharmaceutical systems, including the lesser-studied eutectic and liquid systems, pose as approaches with which to improve the physicochemical properties of these APIs. Currently, one of the biggest development hurdles associated with multi-component systems, and in particular liquid systems, is their intermediate handling. Consequently, this research aims to use a continuous manufacturing technique, hot-melt extrusion (HME), to manufacture multi-component systems while removing their intermediate handling.
Thesis embargoed until 31 December 2026.
|Date of Award||Dec 2021|
|Sponsors||Northern Ireland Department for the Economy|
|Supervisor||Gavin Andrews (Supervisor) & Shu Li (Supervisor)|
- hot-melt extrusion
- multi-component pharmaceutical materials
- therapeutic deep eutectic
- reactive extrusion
- multivariate analysis