Mechanochemical preparation of multi-component pharmaceutical materials for enhanced physicochemical properties

Student thesis: Doctoral ThesisDoctor of Philosophy

Abstract

An extremely large volume of new chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. The synthesis of multi-component pharmaceutical systems, including the lesser-studied eutectic and liquid systems, pose as approaches with which to improve the physicochemical properties of these APIs. Currently, one of the biggest development hurdles associated with multi-component systems, and in particular liquid systems, is their intermediate handling. Consequently, this research aims to use a continuous manufacturing technique, hot-melt extrusion (HME), to manufacture multi-component systems while removing their intermediate handling.
Date of AwardDec 2021
Original languageEnglish
Awarding Institution
  • Queen's University Belfast
SponsorsNorthern Ireland Department for the Economy
SupervisorGavin Andrews (Supervisor) & Shu Li (Supervisor)

Keywords

  • Mechanochemistry
  • hot-melt extrusion
  • eutectic
  • multi-component pharmaceutical materials
  • therapeutic deep eutectic
  • salt
  • reactive extrusion
  • multivariate analysis

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