Photocrosslinked sustained release biodegradable preformed implants for ocular drug delivery

Abstract

The thesis investigates the challenges associated with topical ocular formulations for prolonged treatment of various anterior ocular conditions due to limitations such as rapid elimination in the eye's biological environment. To overcome these challenges, researchers explore the use of photocrosslinked biodegradable implants composed of poly(ethylene glycol) diacrylate (PEGDA), poly(ethylene glycol) methacrylate (PEGMA), and poly(lactic-co-glycolic acid) (PLGA). These hydrogel-based implants demonstrate versatility in delivering small molecule drugs, including timolol maleate, latanoprost, and dexamethasone, for conditions like glaucoma and posterior segment inflammation. The study comprehensively characterises these implants, assessing swelling properties, network parameters, mechanical strength, in vitro drug release profiles, biocompatibility, degradation patterns, and the impact of sterilisation. The findings suggest the potential of photocrosslinked biodegradable implants as a promising approach for sustained and tailored drug delivery to the eye over extended periods.

Thesis is embargoed until 31 July 2029.

Date of Award	Jul 2024
Original language	English
Awarding Institution	Queen's University Belfast
Supervisor	Thakur Raghu Raj Singh (Supervisor), Lalitkumar Vora (Supervisor) & Krishnagoud Manda (Supervisor)