Polymorph control during continuous manufacturing

Abstract

This project aimed to demonstrate a controlled process for polymorph conversion which could be operated on a continuous basis. Both monotropic and enantiotropic polymorphic systems were investigated, with the process required for the monotropic Forms I and II of Hydrochlorothiazide proving unsuitable for continuous manufacturing due to long hold times and a requirement for minimal agitation.

For the enantiotropic Forms III and I of Carbamazepine, a twin screw extrusion process was developed further and paired with quantification of of the polymorphic composition. This system was able to operate at a steady state, while maintaining real-time data collection on the composition of the extruded powders.

Thesis is embargoed until 31 July 2027.

Date of Award	Jul 2024
Original language	English
Awarding Institution	Queen's University Belfast
Sponsors	Northern Ireland Department for the Economy, Science Foundation Ireland & National Science Foundation
Supervisor	Justin Tian (Supervisor) & Gavin Andrews (Supervisor)