Shape-switching studies with cyclophanes and indicator displacement assays with boronic acids

Student thesis: Doctoral ThesisDoctor of Philosophy


This thesis includes the development of indicator displacement assays (IDAs) with a boronic acid receptor, used for the differentiation of Z and E alkene mixtures. An IDA protocol was developed which is ammenable to high-throughput screening and can successfully identify Z and E alkene mixtures with an average absolute error of eight percent. The second research chapter includes the synthesis and analysis of shape-switching cyclophane hosts with a range of molecular guests. This research serves as a contribution towards the field of molecular machines and switches which may gain utility in the fields of drug delivery or catalysis.
Date of AwardJul 2021
Original languageEnglish
Awarding Institution
  • Queen's University Belfast
SponsorsNorthern Ireland Department for the Economy
SupervisorAmilra De Silva (Supervisor) & Eric Anslyn (Supervisor)


  • Supramolecular chemistry
  • fluorescence

Cite this