Shape-switching studies with cyclophanes and indicator displacement assays with boronic acids

Abstract

This thesis includes the development of indicator displacement assays (IDAs) with a boronic acid receptor, used for the differentiation of Z and E alkene mixtures. An IDA protocol was developed which is ammenable to high-throughput screening and can successfully identify Z and E alkene mixtures with an average absolute error of eight percent. The second research chapter includes the synthesis and analysis of shape-switching cyclophane hosts with a range of molecular guests. This research serves as a contribution towards the field of molecular machines and switches which may gain utility in the fields of drug delivery or catalysis.

Date of Award	Jul 2021
Original language	English
Awarding Institution	Queen's University Belfast
Sponsors	Northern Ireland Department for the Economy
Supervisor	Amilra De Silva (Supervisor) & Eric Anslyn (Supervisor)