Abstract
The emerging technology of microfluidics is used here in this thesis to encapsulate both biologic and small molecule active pharmaceutical ingredients within lipid-based nanoformulations. A focus on the use of additive manufacturing for the fabrication of microfluidic devices is given, with analysis into the effect of device parameters on the properties of the final nanoformulation. Using these principles, a bottom-up approach is taken, to succesfully produce formulations ranging from a simple bilayer drug delivery system, to more complex solid lipid nan particles and protein-conjugated nanovessels. Throughout this thesis, a particular focus on the sustainable use of emerging technologies is discussed, with the hope of bettering and prolonging their wide-scale use.Thesis is embargoed until 31 July 2029.
| Date of Award | Jul 2024 |
|---|---|
| Original language | English |
| Awarding Institution |
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| Sponsors | Immunocore Limited |
| Supervisor | Thakur Raghu Raj Singh (Supervisor) & Dimitrios Lamprou (Supervisor) |
Keywords
- Microfluidics
- biologics
- Lipid Nanoparticle