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    Research Statement

    Chromatin reprogramming and cancer metastasis.

    Epithelial-to-Mesenchymal transition (EMT) is a reversible and dynamic process proposed to be co-opted by cancer cells during disease progression, metastasis and therapeutic recalcitrance. Control of the EMT program is orchestrated by a set of master regulators that form an integrated transcriptional network with extensive cross-regulation. Several studies have also suggested that EMT relies on the modulation of chromatin remodelers and epigenetic regulatory mechanisms which remain poorly understood. Modulation of chromatin structure are crucial for cell-type specific activation or repression of gene transcription.

    We previously showed that chromatin reprogramming occurred during EMT while targeting a subset of EMT master regulators in oral cancer (Mohd-Sarip et al., 2017, Cell Reports). The hypothesis is that Nucleosome remodeling and histone deacetylase (NuRD) complex triggers dynamic epigenetic changes leading to EMT-MET in specific cancers.

    To understand the dynamics of chromatin modifiers as a central mechanism underlying tumour development and progression; which is very often paired to the study of epigenetic properties where patterns vary from cancer cell-type to cell-type, it is pertinent to address the impact of chromatin during cancer metastasis. By taking an unbiased proteomics, epigenomics, state-of-the-art microscopy, chromatin-, molecular-, cell-biology and biochemistry-based approaches, novel partners and targets of the NuRD complex will be identified during cellular (de-)differentiation, with a focus on metastasis and EMT-MET.

    Teaching

    Year 3 BSc Biomedical Science_BMS3109_Clinical Biochemistry – Acid base regulation

    Year 2 BSc Biomedical Science_Clinical Genetics - Chromatin remodelling and epigenetic modifiers as therapeutic targets

    MRes (PGT) Translational Medicine_SCM8065_Cancer Biology – Epigenetics and Cancer

    MSc (PGT) Cancer Medicine & Molecular Pathology of Cancer_SCM 8065/8121_Cancer Biology – Epigenetics and Cancer

    Year 1 Medicine_SSC Genomic Impact in Medicine - Chromatin remodelling and epigenetic modifiers as therapeutic targets

    Year 1 Medicine_SSC Mechanisms of Metastasis

     

    Other

    Eager to support and host fellowship applications for postdoc and PhD.

    Willingness to take PhD students

    Yes

    PhD projects

    Open to PhD applications in the fields of:
    - chromatin remodelers
    - epigenetics
    - cancer metastasis
    - proteomics
    - molecular cell biology
    - biochemistry

    Frequent Journals

    • Science

      ISSNs: 0036-8075

      Additional searchable ISSN (Electronic): 1095-9203

      American Association for the Advancement of Science

      Scopus rating (2018): CiteScore 15.21 SJR 13.251 SNIP 7.311

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    • Genes and Development

      ISSNs: 0890-9369

      Cold Spring Harbor Laboratory Press

      Scopus rating (2018): CiteScore 8.26 SJR 7.925 SNIP 1.811

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    • Molecular Cell

      ISSNs: 1097-2765

      Additional searchable ISSN (Electronic): 1097-4164

      Cell Press

      Scopus rating (2018): SJR 12.076 SNIP 2.787

      Journal

    • PLoS One

      ISSNs: 1932-6203

      Additional searchable ISSN (Electronic): 1932-6203

      Public Library of Science

      Scopus rating (2018): CiteScore 3.02 SJR 1.1 SNIP 1.123

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    Contribution to conference papers, events and activities

    ID: 129112100