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    Research Statement

    Chromatin reprogramming and cancer metastasis.

    Epithelial-to-Mesenchymal transition (EMT) is a reversible and dynamic process proposed to be co-opted by cancer cells during disease progression, metastasis and therapeutic recalcitrance. Control of the EMT program is orchestrated by a set of master regulators that form an integrated transcriptional network with extensive cross-regulation. Several studies have also suggested that EMT relies on the modulation of chromatin remodelers and epigenetic regulatory mechanisms which remain poorly understood. Modulation of chromatin structure are crucial for cell-type specific activation or repression of gene transcription.

    We previously showed that chromatin reprogramming occurred during EMT while targeting a subset of EMT master regulators in oral cancer (Mohd-Sarip et al., 2017, Cell Reports). The hypothesis is that Nucleosome remodeling and histone deacetylase (NuRD) complex triggers dynamic epigenetic changes leading to EMT-MET in specific cancers.

    To understand the dynamics of chromatin modifiers as a central mechanism underlying tumour development and progression; which is very often paired to the study of epigenetic properties where patterns vary from cancer cell-type to cell-type, it is pertinent to address the impact of chromatin during cancer metastasis. By taking an unbiased proteomics, epigenomics, state-of-the-art microscopy, chromatin-, molecular-, cell-biology and biochemistry-based approaches, novel partners and targets of the NuRD complex will be identified during cellular (de-)differentiation, with a focus on metastasis and EMT-MET.


    Year 3 BSc Biomedical Science_BMS3109_Clinical Biochemistry – Acid base regulation

    Year 2 BSc Biomedical Science_Clinical Genetics - Chromatin remodelling and epigenetic modifiers as therapeutic targets

    MRes (PGT) Translational Medicine_SCM8065_Cancer Biology – Epigenetics and Cancer

    MSc (PGT) Cancer Medicine & Molecular Pathology of Cancer_SCM 8065/8121_Cancer Biology – Epigenetics and Cancer

    Year 1 Medicine_SSC Genomic Impact in Medicine - Chromatin remodelling and epigenetic modifiers as therapeutic targets

    Year 1 Medicine_SSC Mechanisms of Metastasis



    Eager to support and host fellowship applications for postdoc and PhD.

    Willingness to take PhD students


    PhD projects

    Open to PhD applications in the fields of:
    - chromatin remodelers
    - epigenetics
    - cancer metastasis
    - proteomics
    - molecular cell biology
    - biochemistry

    Frequent Journals

    • Science

      ISSNs: 0036-8075

      Additional searchable ISSN (Electronic): 1095-9203

      American Association for the Advancement of Science

      Scopus rating (2018): CiteScore 15.21 SJR 13.251 SNIP 7.311


    • Genes and Development

      ISSNs: 0890-9369

      Cold Spring Harbor Laboratory Press

      Scopus rating (2018): CiteScore 8.26 SJR 7.925 SNIP 1.811


    • Molecular Cell

      ISSNs: 1097-2765

      Additional searchable ISSN (Electronic): 1097-4164

      Cell Press

      Scopus rating (2018): SJR 12.076 SNIP 2.787


    • PLoS One

      ISSNs: 1932-6203

      Additional searchable ISSN (Electronic): 1932-6203

      Public Library of Science

      Scopus rating (2018): CiteScore 3.02 SJR 1.1 SNIP 1.123


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    Contribution to conference papers, events and activities

    ID: 129112100