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    Research Statement

    Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) with the  particular focus  on the MSC based   cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a  spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill. Our central goal is to understand how MSC work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to  identify new therapeutic targets for ARDS and sepsis. The current research projects are investigating effects of MSC on pulmonary macrophage polarisation, MSC modulation of distal lung endothelial and epithelial cell functions  and more recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.

     

    Willingness to take PhD students

    Yes

    PhD projects

    Dr Krasnodembskaya is open to PhD applications from motivated and enthusiastic students who is interested in Mesenchymal Stem Cells biology and therapeutic applications in lung diseases. Potential PhD projects on the following topics are available (the list is not exhaustive) :
    Investigation of the role of MSC exosomal miRNAs in epithelial and endothelial repair in ARDS
    The role of MSC mitochondrial transfer in lung regeneration
    The role of apoptosis in MSC therapeutic effects in ARDS

    Frequent Journals

    • Thorax

      ISSNs: 0040-6376, 1468-3296

      BMJ Publishing Group

      Scopus rating (2017): CiteScore 4.1 SJR 3.381 SNIP 2.215

      Journal

    • American Journal of Respiratory and Critical Care Medicine

      ISSNs: 1073-449X

      Additional searchable ISSN (Electronic): 1535-4970

      American Thoracic Society

      Scopus rating (2017): CiteScore 5.1 SJR 5.942 SNIP 2.998

      Journal

    • Stem Cells

      ISSNs: 1066-5099

      Additional searchable ISSN (Electronic): 1549-4918

      AlphaMed Press

      Scopus rating (2017): CiteScore 5.52 SJR 2.796 SNIP 1.383

      Journal

    • European Respiratory Journal

      ISSNs: 0903-1936

      Additional searchable ISSN (Electronic): 1399-3003

      EUROPEAN RESPIRATORY SOC JOURNALS LTD

      Scopus rating (2017): CiteScore 5.16 SJR 3.788 SNIP 2.396

      Journal

    • Lung

      ISSNs: 0341-2040

      Springer

      Scopus rating (2017): CiteScore 1.85 SJR 0.79 SNIP 0.831

      Journal

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    Contribution to conference papers, events and activities

    ID: 2586716