Bettina Schock
    Phone: +44 (0)28 9097 2258, +44 (0)28 906 32731

    For media contact email comms.office@qub.ac.uk
    or call +44(0)2890 973091.

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    Research Interests

    I have been actively researching inflammation and immunity in pulmonary diseases since my PhD with a Scholarship from the German Academic Exchange Service (DAAD). After a post-doctoral training at UC Davis (USA), I returned to Queen’s to develop my expertise in regulators of inflammation in chronic airway diseases such as Cystic Fibrosis (CF) and Asthma. My current work focuses on the role of the innate immunity in epithelial inflammation and its regulation. Our results in CF confirmed prolonged TLR4 signalling and persistent NF-kB activation associated with reduced lysosomal degradation and increased TLR4 recycling in CF. Subsequently I was the first to describe a dysregulation and lack of the NF-kB regulator A20 in CF, which was highly correlated to lung function in these patients. We also showed that pharmacological induction of A20 is anti-inflammatory, supporting the importance of A20 in NF-kB driven inflammation. Based on this proof of principle, my laboratory applied bioinformatics to predict drugs already licensed for use in humans to induce A20 as a potential therapeutic intervention for people with CF (Malcomson B et al. PNAS 2016). However, the blunted response of these repurposed drugs on A20 in chronic airway inflammation lead to the current investigations of potential A20 regulators. Additionally, based on the recent findings on A20 I am extending my research programme to potential drug development programmes with QUB. I am dedicated to develop an understanding and enthusiasm for research in under-graduate and post-graduate students. I am committed to inter-disciplinary research with a major focus on translational work to improve diagnosis or therapies for patients with chronic airway diseases.

    Willingness to take PhD students

    Yes

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    Frequent Journals

    • Free Radical Biology and Medicine

      ISSNs: 0891-5849

      Elsevier Inc.

      Scopus rating (2017): CiteScore 5.68 SJR 2.178 SNIP 1.482

      Journal

    • American Journal of Physiology - Lung Cellular and Molecular Physiology

      ISSNs: 1040-0605

      Additional searchable ISSN (Electronic): 1522-1504

      American Physiological Society

      Scopus rating (2017): CiteScore 4.22 SJR 1.844 SNIP 0.997

      Journal

    • European Respiratory Journal

      ISSNs: 0903-1936

      Additional searchable ISSN (Electronic): 1399-3003

      EUROPEAN RESPIRATORY SOC JOURNALS LTD

      Scopus rating (2017): CiteScore 5.16 SJR 3.788 SNIP 2.396

      Journal

    • Clinical & Experimental Allergy

      ISSNs: 0954-7894, 0009-9090

      Additional searchable ISSN (Electronic): 1365-2222

      Wiley-Blackwell

      Scopus rating (2017): CiteScore 3.98 SJR 1.979 SNIP 1.392

      Journal

    • Allergy

      ISSNs: 0105-4538

      Additional searchable ISSN (Electronic): 1398-9995

      Wiley-Blackwell

      Scopus rating (2017): CiteScore 6.23 SJR 2.702 SNIP 2.332

      Journal

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