Bianca Plouffe

    Bianca Plouffe

    Vice-Chancellor's Fellow

    For media contact email comms.office@qub.ac.uk
    or call +44(0)2890 973091.

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    Research Interests

    G protein-coupled receptors (GPCRs) represent the largest family of cell surface proteins. Agonist binding to GPCRs activates G proteins regulating many cellular effectors. Classically, G protein activation occurs at the plasma membrane and is rapidly terminated by β-arrestin recruitment to the activated GPCRs, promoting G protein uncoupling from receptor, GPCR internalisation and signalling arrest. 

    However, recent studies revealed that upon internalisation, some GPCRs continue to activate G proteins from internal compartments leading to sustained production of second messengers far from the plasma membrane. This different spatiotemporal signalling profile allows distinct cellular functions from the ones occurring at the plasma membrane that can be exploited in the near future to design new pharmacological approaches. My research programme aims to tackle important questions underlying this novel signalling mode.

    Frequent Journals

    • Journal of Medicinal Chemistry

      ISSNs: 0022-2623

      American Chemical Society

      Scopus rating (2018): CiteScore 6.23 SJR 2.287 SNIP 1.676

      Journal

    • Proceedings of the National Academy of Sciences

      ISSNs: 0027-8424

      Additional searchable ISSN (Electronic): 1091-6490

      NATL ACAD SCIENCES

      Scopus rating (2018): CiteScore 8.58 SJR 5.601 SNIP 2.539

      Journal

    • Bioorganic & Medicinal Chemistry

      ISSNs: 0968-0896

      Additional searchable ISSN (Electronic): 1464-3391

      Elsevier Limited

      Scopus rating (2018): CiteScore 2.85 SJR 0.747 SNIP 0.877

      Journal

    • Science Signaling

      ISSNs: 1945-0877

      Additional searchable ISSN (Electronic): 1937-9145

      American Association for the Advancement of Science

      Scopus rating (2018): SJR 3.169 SNIP 1.164

      Journal

    • British Journal of Cancer

      ISSNs: 0007-0920, 1532-1827

      Additional searchable ISSN (Electronic): 1532-1827

      Nature Publishing Group

      Scopus rating (2018): CiteScore 5.52 SJR 2.848 SNIP 1.654

      Journal

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