Brian Walker

    Brian Walker

    Emeritus Professor

    For media contact email comms.office@qub.ac.uk
    or call +44(0)2890 973091.

    Scopus Citations 0

    1. 2018
    2. Published

      A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea

      Zhang, L., Chen, X., Wu, Y., Zhou, M., Ma, C., Xi, X., Chen, T., Walker, B., Shaw, C. & Wang, L., 11 Apr 2018, In : Scientific Reports. 8, 9 p., 5851., 5851

      Research output: Contribution to journalArticle

    3. 2017
    4. Published

      Detection and inhibition of ENaC-activating proteases associated with airway dehydration in COPD

      Martin, L., Reihill, J., Douglas, L., Ferguson, T. & Walker, B., Sep 2017, In : European Respiratory Journal. 50, Suppl 61, PA4933., PA4933

      Research output: Contribution to journalMeeting abstract

    5. Published

      Neutrophil Elastase Activity is Associated with Exacerbations and Lung Function Decline in Bronchiectasis

      Chalmers, J. D., Moffitt, K. L., Suarez-Cuartin, G., Sibila, O., Finch, S., Furrie, E., Dicker, A., Wrobel, K., Elborn, J. S., Walker, B., Martin, S. L., Marshall, S. E., Huang, J. T-J. & Fardon, T. C., 15 May 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1384-1393

      Research output: Contribution to journalArticle

    6. Published

      A Structural and Functional Analogue of a Bowman Birk-type Protease Inhibitor from Odorrana Schmackeri

      Wu, Y., Long, Q., Xu, Y., Guo, S., Chen, T., Wang, L., Zhou, M., Zhang, Y., Shaw, C. & Walker, B., Apr 2017, In : Bioscience Reports. 37, 2

      Research output: Contribution to journalArticle

    7. 2016
    8. Published

      How specific are fluorogenic substrates designed to analyse active protease biomarkers of respiratory disease?

      Robb, C., Ferguson, T., Moffitt, K., Downey, D., McCafferty, D., Ribeiro, D., Martin, L. & Walker, B., Dec 2016, In : Thorax. 71, Suppl 3, p. A79-A80 2 p.

      Research output: Contribution to journalMeeting abstract

    9. Published

      DEVELOPMENT OF A PROTEASETAG® LATERAL FLOW DEVICE FOR DETECTION OF ACTIVE NEUTROPHIL ELASTASE IN THE CLINIC

      McCafferty, D., Robb, C., Ferguson, T., Moffitt, K., Walker, B. & Martin, L., Oct 2016, In : Pediatric Pulmonology. 51, S45, p. 280 1 p.

      Research output: Contribution to journalMeeting abstract

    10. Published

      NE ULTRA – A NOVEL PROTEASETAG® FOR THE INHIBITION AND DETECTION OF NEUTROPHIL ELASTASE IN BIOLOGICAL SAMPLES

      Ferguson, T., Robb, C., Moffitt, K., Martin, L., McCafferty, D. & Walker, B., Oct 2016, In : Pediatric Pulmonology. 51, S45, p. 281 1 p.

      Research output: Contribution to journalMeeting abstract

    11. Published

      Inhibition of protease-ENaC signaling improves mucociliary function in cystic fibrosis airways

      Reihill, J. A., Walker, B., Hamilton, R. A., Ferguson, T. E. G., Elborn, J. S., Stutts, M. J., Harvey, B. J., Saint-Criq, V., Hendrick, S. M. & Martin, S. L., Sep 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 6, p. 701-710 10 p.

      Research output: Contribution to journalArticle

    12. Published

      A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity

      Ferguson, T. E. G., Reihill, J. A., Walker, B., Hamilton, R. A. & Martin, S. L., 26 Jul 2016, In : PLoS ONE. 11, 7, 9 p., e0159868., e0159868

      Research output: Contribution to journalArticle

    13. 2015
    14. Published

      Development of a Novel Assay for the Detection of Active Neutrophil Elastase in Patients with Chronic Obstructive Pulmonary Disease

      Moffitt, KL., Martin, SL., Chalmers, J. & Walker, B., Dec 2015, In : Thorax. 70, Suppl 3, p. A126-A127

      Research output: Contribution to journalMeeting abstract

    15. Published

      A novel inhibitor of channel activating proteases: Putting the CAP on ENaC

      Reihill, J. A., Walker, B., Harvey, B., Stutts, J., Elborn, J. S. & Martin, S. L., Oct 2015, In : Pediatric Pulmonology. 50, Suppl 41, p. 229 1 p.

      Research output: Contribution to journalMeeting abstract

    16. Published

      A Novel Inhibitor of Channel Activating Proteases: Putting the Cap on ENAC

      Reihill, J. A., Walker, B., Harvey, B., Stutts, J. & Elborn, J., Oct 2015, In : Pediatric Pulmonology. 50, S41, p. S229 1 p.

      Research output: Contribution to journalMeeting abstract

    17. Published

      Utilisation of a novel ProteaseTag™ activity immunoassay for the specific measurement of neutrophil elastase in BAL from children with cystic fibrosis

      Moffitt, K. L., McNally, P., Linnane, B., Walker, B. & Martin, S., Oct 2015, In : Pediatric Pulmonology. 50, Suppl 41, p. 266-267

      Research output: Contribution to journalMeeting abstract

    18. Published
    19. Published

      Development of Novel Activity-Based Probes for the Detection of Serine Proteases

      Ferguson, T., Walker, B. & Martin, S. L., 13 Apr 2015.

      Research output: Contribution to conferencePoster

    20. Published

      Inhibition of matrix metalloproteinases associated with chronic wounds

      Robb, C., Walker, B. & Martin, L., 13 Apr 2015.

      Research output: Contribution to conferencePaper

    21. 2014
    22. Published

      Targeting trypsin-like proteases in cystic fibrosis airways

      Reihill, J., Walker, B., Elborn, J. & Martin, L., 23 Oct 2014.

      Research output: Contribution to conferencePaper

    23. Published

      Synergistic effects of proteasome inhibitor carfilzomib in combination with tyrosine kinase inhibitors in imatinib-sensitive and -resistant chronic myeloid leukemia models

      Crawford, LJ., Chan, ET., Aujay, M., Holyoake, TL., Melo, JV., Jorgensen, HG., Suresh, S., Walker, B. & Irvine, AE., Mar 2014, In : ONCOGENESIS. 3, 2, 10 p., e90., e90

      Research output: Contribution to journalArticle

    24. 2013
    25. Published

      Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

      Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

      Research output: Contribution to journalArticle

    26. Published
    27. Published
    28. Unpublished

      The inhibition of matrix metalloproteinases associated with inflammatory disease

      Robb, C., Martin, L. & Walker, B., 15 Apr 2013, (Unpublished).

      Research output: Contribution to conferencePaper

    29. Published

      Design and efficacy of peptide mimetics of LL-37

      Irwin, C., Yu, Y., Walker, B. & Lundy, F., 2013, In : Journal of Dental Research.

      Research output: Contribution to journalMeeting abstract

    30. Published

      Evaluating the antifungal activity of a novel truncated antimicrobial peptide

      Lukes, L., Luo, Y., Yu, Y., Walker, B. & Lundy, F., 2013, In : Journal of Dental Research.

      Research output: Contribution to journalMeeting abstract

    31. 2012
    32. Published

      Chymotrypsin-like serine proteinases are involved in the maintenance of cell viability

      Moffitt, K. L., Walker, B. & Martin, S. L., Dec 2012, In : Biochimie. 94, 12, p. 2582-2589 8 p.

      Research output: Contribution to journalArticle

    33. Published
    34. Published
    35. Published
    36. Published
    37. Published
    38. Published
    39. Published

      Mapping biological to clinical phenotypes during the development (21 days) and resolution (21 days) of experimental gingivitis

      Scott, A. E., Milward, M., Linden, G., Matthew, J. B., Carlile, M. J., Lundy, F., Naeeni, M. A., Martin, L., Walker, B., Kinane, D., Brock, G. R. & Chapple, I. L. C., Feb 2012, In : Journal of Clinical Periodontology. 39, 2, p. 123-131 9 p.

      Research output: Contribution to journalArticle

    40. 2011
    41. Published
    42. Published

      Comprehensive Inhibitor Profiling Of The Proteus Mirabilis Metalloprotease Virulence Factor Zapa (Mirabilysin)

      Carson, L., Cathcart, G., Scott, C., Hollenberg, M. D., Walker, B., Ceri, H. & Gilmore, B., Aug 2011, In : Biochimie. 93, 10, p. 1824-1827 4 p.

      Research output: Contribution to journalArticle

    43. Published

      A Novel Bacterial Protease-triggered Polymeric Antimicrobial Release System

      Chen, W., Walker, B., Gorman, S. & Gilmore, B., Jul 2011, p. 103.

      Research output: Contribution to conferencePoster

    44. Published
    45. Published
    46. Published

      Proteasome inhibitors in cancer therapy

      Crawford, L., Walker, B. & Irvine, A., Jun 2011, In : Journal of Cell Communication and Signaling. 5, 2, p. 101-110 10 p.

      Research output: Contribution to journalArticle

    47. Published

      Synthesis and biological evaluation of antioxidant peptides as putative treatment for Alzheimer's disease

      Tegazzini, D., Martin, L. & Walker, B., Jun 2011, p. 490.

      Research output: Contribution to conferencePaper

    48. Published

      A modified Tat peptide for selective intracellular delivery of macromolecules

      Murphy, D. J., Walker, B., Greer, B., Harriott, P. & Martin, S. L., May 2011, In : Journal of Pharmacy and Pharmacology. 63, 5, p. 611-618 8 p.

      Research output: Contribution to journalArticle

    49. 2010
    50. Published
    51. Published

      Methods for measuring proteasome activity: Current limitations and future developments

      Liggett, A., Crawford, L., Walker, B., Morris, T. & Irvine, A., Nov 2010, In : Leukemia research. 34, 11, p. 1403-1409 7 p.

      Research output: Contribution to journalArticle

    52. Published

      Inhibition of Pseudomonas elastase, LasB, attenuates biofilm formation and increases antimicrobial susceptibility in vitro

      Gilmore, B., Cathcart, G. & Walker, B., Oct 2010, p. 1385-1386. 2 p.

      Research output: Contribution to conferencePaper

    53. Published
    54. Published

      The Role of Functional Amyloid in Bacterial Biofilm Formation and Antimicrobial Susceptibility

      Currie, K., Gorman, S., Walker, B. & Gilmore, B., Oct 2010, p. 1392-1393. 2 p.

      Research output: Contribution to conferencePaper

    55. Published
    56. Published

      The effects of bacterial stimulation on prostasin levels within the cystic fibrosis lung

      Moffitt, K., Einarsson, G., Walker, B., Elborn, J. & Martin, L., Jun 2010, p. S18-S18. 1 p.

      Research output: Contribution to conferencePaper

    57. Published

      From sentencing to execution--the processes of apoptosis.

      Moffitt, K., Martin, L. & Walker, B., May 2010, In : Journal of Pharmacy and Pharmacology. 62(5), 5, p. 547-562 16 p.

      Research output: Contribution to journalArticle

    58. Published

      Proteases implicated in apoptosis: old and new.

      Moffitt, K., Martin, L. & Walker, B., May 2010, In : Journal of Pharmacy and Pharmacology. 62(5), 5, p. 563-576 14 p.

      Research output: Contribution to journalArticle

    59. 2009
    60. Published
    61. Published

      Inhibitor profiling of the Pseudomonas aeruginosa virulence factor LasB using N-alpha mercaptoamide template-based inhibitors

      Cathcart, G., Gilmore, B., Greer, B., Harriott, P. & Walker, B., 01 Nov 2009, In : Bioorganic & Medicinal Chemistry Letters. 19, 21, p. 6230-6232 3 p.

      Research output: Contribution to journalArticle

    62. Published

      Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis

      Burden, R. E., Gormley, J. A., Jaquin, T. J., Small, D., Quinn, D. J., Hegarty, S., Ward, C., Walker, B., Johnston, J. A., Olwill, S. A. & Scott, C. J., 01 Oct 2009, In : Clinical Cancer Research. 15, 19, p. 6042-6051 10 p.

      Research output: Contribution to journalArticle

    63. Published
    64. Published
    65. Published
    66. Published

      FMRFamide-related peptides (FaRPs): A new family of peptides from amphibian defensive skin secretions

      Wang, L., Smyth, A., Johnsen, A. H., Zhou, M., Chen, T., Walker, B. & Shaw, C., 05 Jun 2009, In : Biochemical and Biophysical Research Communications. 383, 3, p. 314-319 6 p.

      Research output: Contribution to journalArticle

    67. Published

      EVALUATION OF THE PROTEASOMAL EFFECTS OF TYROSINE KINASE INHIBITORS AND BORTEZOMIB IN CHRONIC MYELOID LEUKAEMIA

      McCloskey, S., McMullin, M. F., Walker, B. & Irvine, A., Jun 2009, In : HAEMATOLOGICA. 94, p. 125-125 1 p.

      Research output: Contribution to journalArticle

    68. Published

      NOVEL WHOLE CELL ASSAYS TO MONITOR PROTEASOME ACTIVITY IN MULTIPLE MYELOMA

      Liggett, A., Morris, T., Walker, B. & Irvine, A., Jun 2009, In : HAEMATOLOGICA. 94, p. 378-378 1 p.

      Research output: Contribution to journalArticle

    69. Published

      pSK-A NOVEL AMPHIBIAN SKIN BOWMAN-BIRK-LIKE TRYPSIN AND TMPRSS2 INHIBITOR

      Chen, T., Hawthorne, S., Chen, T., Shaw, C. & Walker, B., Jun 2009, In : Biopolymers. 92, p. 359-359 1 p.

      Research output: Contribution to journalArticle

    70. Published
    71. Published
    72. Published
    73. Published

      Tyrosine kinase and proteasome inhibition alter proteasome expression in BCR-ABL positive cell lines

      McCloskey, S., McMullin, M. F., Walker, B. & Irvine, A., Apr 2009, In : British Journal of Haematology. 145, p. 21-22 2 p.

      Research output: Contribution to journalArticle

    74. Published

      Proteasome proteolytic profile is linked to Bcr-Abl expression.

      Crawford, L., Windrum, P., Magill, L., Melo, J. V., McCallum, L., McMullin, M., Ovaa, H., Walker, B. & Irvine, A., Mar 2009, In : Experimental Hematology. 37(3), 3, p. 357-366 10 p.

      Research output: Contribution to journalArticle

    75. Published

      Development of a Whole-Cell Assay to Monitor Proteasome Activity in Multiple Myeloma

      Liggett, A., Irvine, A., Morris, T. & Walker, B., 2009, In : CLINICAL LYMPHOMA & MYELOMA. 9, p. S119-S119 1 p.

      Research output: Contribution to journalArticle

    76. Published

      Enzyme Kinetic Measurements for a Combinatorial Library of Inhibitors of Pseudomonas Elastase

      Cathcart, G., Gilmore, B. & Walker, B., 2009

      Research output: Non-textual formWeb publication/site

    77. 2008
    78. Published

      Ber-Abl Positive Cells Display Increased Proteasome Activity and Greater Sensitivity to Proteasome Inhibition

      Crawford, L., Windrum, P., Magill, L., Melo, J. V., McCallum, L., McMullin, M. F., Ovaa, H., Walker, B. & Irvine, A., Dec 2008, In : Blood. 112, p. 1095-1096 2 p.

      Research output: Contribution to journalArticle

    79. Published

      G-CSF increases proteasome activity in myeloid cells

      McCloskey, S. M., Windrum, P., McMullin, M., Walker, B. & Irvine, A., Nov 2008, In : British Journal of Haematology. 143, 4, p. 598-601 4 p.

      Research output: Contribution to journalArticle

    80. Published

      Development of novel inhibitors and substrates for Pseudomonas elastase, a potential anti-biofilm target in Pseudomonas aeruginosa

      Cathcart, G., Gilmore, B. & Walker, B., Oct 2008, p. Suppl. 1-A20. 20 p.

      Research output: Contribution to conferencePaper

    81. Published

      Expedited solid-phase synthesis and utilization of affinity-based probes for the serine proteases

      Gilmore, B. & Walker, B., Oct 2008, p. Suppl. 1-A33. 33 p.

      Research output: Contribution to conferencePaper

    82. Published

      Novel dermaseptin, adenoregulin and caerin homologs from the Central American red-eyed leaf frog, Agalychnis callidryas, revealed by functional peptidomics of defensive skin secretion

      Wang, L., Zhou, M., McClelland, A., Reilly, A., Chen, T., Gagliardo, R., Walker, B. & Shaw, C., Oct 2008, In : Biochimie. 90, 10, p. 1435-1441 7 p.

      Research output: Contribution to journalArticle

    83. Published

      Discovery of novel cathepsin S inhibitors by pharmacophore-based virtual high-throughput screening

      Markt, P., McGoohan, C., Walker, B., Kirchmair, J., Feldmann, C. L., De Martino, G., Spitzer, G., Distinto, S., Schuster, D., Wolber, G., Laggner, C. & Langer, T., Aug 2008, In : JOURNAL OF CHEMICAL INFORMATION AND MODELING. 48, 8, p. 1693-1705 13 p.

      Research output: Contribution to journalArticle

    84. Published

      Novel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors

      Quan, Q., Zhou, M., Chen, W., Chen, T., Walker, B. & Shaw, C., Aug 2008, In : Peptides. 29 (8), 8, p. 1456-1460 5 p.

      Research output: Contribution to journalArticle

    85. Published

      Degradation of host defence molecules by CF-related pathogens grown as biofilms

      Einarsson, G., Martin, L., Walker, B., Elborn, J. & McDowell, A., Jun 2008, p. S43-S43. 1 p.

      Research output: Contribution to conferencePaper

    86. Published

      The therapeutic potential of the proteasome

      McCloskey, S. M., McMullin, M., Walker, B. & Irvine, A., Jun 2008, In : Hematological Oncology. 26, 2, p. 73-81 9 p.

      Research output: Contribution to journalArticle

    87. Published

      Activity-based selection of a proteolytic species using ribosome display.

      Quinn, D., Cunningham, S., Walker, B. & Scott, C., 23 May 2008, In : Biochemical and Biophysical Research Communications. 370(1), 1, p. 77-81 5 p.

      Research output: Contribution to journalArticle

    88. Published
    89. Published

      Profiling proteasome activity in whole cells

      Liggett, A., Morris, T., Walker, B. & Irvine, A., 2008, In : British Journal of Haematology. 141, p. 28-28 1 p.

      Research output: Contribution to journalArticle

    90. Published

      Profiling the proteasome in BCR-ABL positive cell lines

      McCloskey, S. M., McMullin, M., Walker, B. & Irvine, A., 2008, In : British Journal of Haematology. 141, p. 44-45 2 p.

      Research output: Contribution to journalArticle

    91. Published

      Proteasome inhibitors: a therapeutic strategy for haematological malignancy

      Crawford, L., Walker, B. & Irvine, A., 2008, In : Frontiers in bioscience : a journal and virtual library. 13, 11, p. 4285-4296 12 p.

      Research output: Contribution to journalArticle

    92. 2007
    93. Published
    94. Published
    95. Published
    96. Published

      The emerging role of serine proteases in apoptosis

      Moffitt, K., Martin, L. & Walker, B., Jun 2007, In : Biochemical society transactions. 35, 3, p. 559-560 2 p.

      Research output: Contribution to journalArticle

    97. Published

      Inhibition of cathepsin L-like proteases by cathepsin V propeptide

      Burden, R., Snoddy, P., Jefferies, C. A., Walker, B. & Scott, C., 01 May 2007, In : Biological Chemistry. 388(5), 5, p. 541-545 5 p.

      Research output: Contribution to journalArticle

    98. Published

      Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.

      Flannery, T., McConnell, R. S., McQuaid, S., McGregor, G., Mirakhur, M., Martin, L., Scott, C., Burden, R., Walker, B., McGoohan, C. & Johnston, P., Apr 2007, In : British Journal of Neurosurgery. 21, 2, p. 204-209 6 p.

      Research output: Contribution to journalArticle

    99. Published

      Synthesis of Peptidyl Ene Diones: Selective Inactivators of the Cysteine Proteinases

      Darkins, P., Gilmore, B., Hawthorne, S., Healy, A., Moncrieff, H., McCarthy, N., McKervey, M. A., Bromme, D., Pagano, M. & Walker, B., Mar 2007, In : Chemical Biology & Drug Design. 69(3), 3, p. 170-179 10 p.

      Research output: Contribution to journalArticle

    100. Published

      Survival analysis of first-line tamoxifen versus aromatase inhibitors for estrogen-positive metastatic breast cancer in postmenopausal women - a BC perspective

      Kyritsis, V., De Lemos, M., Walker, B., Kennecke, H. & Nakashima, L., 2007, In : Breast Cancer Research and Treatment. 106, p. S112-S113 2 p.

      Research output: Contribution to journalArticle

    101. 2006
    102. Published
    103. Published
    104. Published
    105. Published
    106. Published
    107. Published

      Cathepsin S expression: An independent prognostic factor in glioblastoma tumours - A pilot Study

      Scott, C., Flannery, T., McQuaid, S., McGoohan, C., McConnell, R. S., McGregor, G., Mirakhur, M., Hamilton, P., Diamond, J., Cran, G., Walker, B., Martin, L., Ellison, D., Patel, C., Nicholson, C., Mendelow, D., McCormick, D. & Johnston, P., 15 Aug 2006, In : International Journal of Cancer. 119, 4, p. 854-860 7 p.

      Research output: Contribution to journalArticle

    108. Published

      Dipeptide Proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha)

      Gilmore, B., Lynas, J. F., Scott, C., McGoohan, C., Martin, L. & Walker, B., 28 Jul 2006, In : Biochemical and Biophysical Research Communications. 346(2), 2, p. 436-446 11 p.

      Research output: Contribution to journalArticle

    109. Published
    110. Published

      Structural and functional analogs of the novel mammalian neuropeptide, neuromedin S (NmS), in the dermal venoms of Eurasian bombinid toads.

      Chen, T., Zhou, M., Walker, B., Harriott, P., Mori, K., Miyazato, M., Kangawa, K. & Shaw, C., 23 Jun 2006, In : Biochemical and Biophysical Research Communications. 345(1), 1, p. 377-384 8 p.

      Research output: Contribution to journalArticle

    111. Published

      Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132.

      Walker, B., Ovaa, H., Chauhan, D., Crawford, L., Anderson, K. C., Morris, T. C. M. & Irvine, A. E., 15 Jun 2006, In : Cancer Research. 66(12), 12, p. 6379-6386 8 p.

      Research output: Contribution to journalArticle

    112. Published

      Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs

      Chen, T., Zhou, M., Chen, W., Lorimer, J., Rao, P., Walker, B. & Shaw, C., May 2006, In : Genomics. 87(5), 5, p. 638-644 7 p.

      Research output: Contribution to journalArticle

    113. Published

      Peptides containing acylated C-terminal gem diamines: novel irreversible inactivators of the cysteine and serine proteinases.

      Gilmore, B., Walker, B., Harriott, P., Healy, A. & Lynas, J. F., May 2006, In : Chemical Biology & Drug Design. 67(5), 5, p. 364-369 6 p.

      Research output: Contribution to journalArticle

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