David Gonzalez de Castro

    David Gonzalez de Castro

    Clinical Professor

    Phone: +44 (0)28 9097 2772

    For media contact email comms.office@qub.ac.uk
    or call +44(0)2890 973091.

    Scopus Citations 139

    1. 2019
    2. Early online date
    3. Early online date

      Analysis of KRAS, NRAS, BRAF, PIK3CA and TP53 mutations in a large prospective series of locally advanced rectal cancer patients

      Sclafani, F., Hulkki Wilson, S., Cunningham, D., Gonzalez De Castro, D., Kalaitzaki, E., Begum, R., Wotherspoon, A., Capdevila, J., Glimelius, B., Roselló, S., Thomas, J., Tait, D., Brown, G., Oates, J. & Chau, I., 14 Jun 2019, In : International Journal of Cancer.

      Research output: Contribution to journalArticle

    4. Published

      Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial

      Hall, A., Buckley, H. L., Flanagan, L., Gonzalez de Castro, D., Farnell, K., Moss, L., Gregory, R., Newbold, K., Du, Y., Flux, G. & Wadsley, J., 14 Jun 2019, In : BMC Cancer. 19, 10 p., 582., 582

      Research output: Contribution to journalArticle

    5. Published

      The relevance of TP53 for CLL diagnostics

      Catherwood, M. A., Gonzalez de Castro, D., Donaldson, D., Clifford, R., Mills, K. I. & Thornton, P. D., 16 Apr 2019, In : Journal of Clinical Pathology. 72, p. 343-346 4 p.

      Research output: Contribution to journalReview article

    6. 2018
    7. Early online date

      Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations

      Xochelli, A., Bikos, V., Polychronidou, E., Galigalidou, C., Agathangelidis, A., Charlotte, F., Moschonas, P., Davis, Z., Colombo, M., Roumelioti, M., Sutton, L-A., Groenen, P., van den Brand, M., Boudjoghra, M., Algara, P., Traverse-Glehen, A., Ferrer, A., Stalika, E., Karypidou, M., Kanellis, G. & 25 othersKalpadakis, C., Mollejo, M., Pangalis, G., Vlamos, P., Amini, R-M., Pospisilova, S., Gonzalez, D., Ponzoni, M., Anagnostopoulos, A., Giudicelli, V., Lefranc, M-P., Espinet, B., Panagiotidis, P., Piris, M. A., Du, M-Q., Rosenquist, R., Papadaki, T., Belessi, C., Ferrarini, M., Oscier, D., Tzovaras, D., Ghia, P., Davi, F., Hadzidimitriou, A. & Stamatopoulos, K., 28 Nov 2018, In : Journal of Pathology.

      Research output: Contribution to journalArticle

    8. Early online date

      Circulating tumour DNA is a potential biomarker for disease progression and response to targeted therapy in advanced thyroid cancer

      Allin, D. M., Shaikh, R., Carter, P., Thway, K., Sharabiani, M. T. A., Gonzalez-de-Castro, D., O'Leary, B., Garcia-Murillas, I., Bhide, S., Hubank, M., Harrington, K., Kim, D. & Newbold, K., 22 Sep 2018, In : European journal of cancer (Oxford, England : 1990). 103, p. 165-175

      Research output: Contribution to journalArticle

    9. Early online date

      Ultra-Sensitive Mutation Detection and Genome-Wide DNA Copy Number Reconstruction by Error-Corrected Circulating Tumor DNA Sequencing

      Mansukhani, S., Barber, L. J., Kleftogiannis, D., Moorcraft, S. Y., Davidson, M., Woolston, A., Proszek, P. Z., Griffiths, B., Fenwick, K., Herman, B., Matthews, N., O'Leary, B., Hulkki, S., Gonzalez De Castro, D., Patel, A., Wotherspoon, A., Okachi, A., Rana, I., Begum, R., Davies, M. N. & 10 othersPowles, T., von Loga, K., Hubank, M., Turner, N., Watkins, D., Chau, I., Cunningham, D., Lise, S., Starling, N. & Gerlinger, M., 20 Sep 2018, In : Clinical Chemistry.

      Research output: Contribution to journalArticle

    10. Published

      Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme

      Lindsay, C. R., Shaw, E. C., Blackhall, F., Blyth, K. G., Brenton, J. D., Chaturvedi, A., Clarke, N., Dick, C., Evans, T. R. J., Hall, G., Hanby, A. M., Harrison, D. J., Johnston, S. R. D., Mason, M. D., Morton, D., Newton-Bishop, J., Nicholson, A. G., Oien, K. A., Popat, S., Rassl, D. & 9 othersSharpe, R., Taniere, P., Walker, I., Wallace, W. A., West, N. P., Butler, R., Gonzalez de Castro, D., Griffiths, M. & Johnson, P. W. M., 05 Sep 2018, In : ESMO Open. 3, 6, 9 p., e000408., e000408

      Research output: Contribution to journalArticle

    11. Published

      Detection of EGFR Variants in Plasma: A Multilaboratory Comparison of a Real-Time PCR EGFR Mutation Test in Europe

      Keppens, C., Palma, J. F., Das, P. M., Scudder, S., Wen, W., Normanno, N., van Krieken, J. H., Sacco, A., Fenizia, F., Gonzalez de Castro, D., Hönigschnabl, S., Kern, I., Lopez-Rios, F., Lozano, M. D., Marchetti, A., Halfon, P., Schuuring, E., Setinek, U., Sorensen, B., Taniere, P. & 3 othersTiemann, M., Vosmikova, H. & Dequeker, E. M. C., Jul 2018, In : Journal of Molecular Diagnostics. 20, 4, p. 483-494 12 p.

      Research output: Contribution to journalArticle

    12. Early online date

      Gastrointestinal Stromal Tumor With Multiple Primary Tyrosine Kinase Mutations-Clinicopathologic and Molecular Characterization

      Wong, N. A. C. S., Taniere, P., Walsh, S., Wallace, A., Nonaka, D., Jones, T. & Gonzalez, D., 04 May 2018, In : APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY. 5 p.

      Research output: Contribution to journalArticle

    13. Published
    14. Published

      Treatment and Survival Outcome of BRAF-Mutated Metastatic Colorectal Cancer A Retrospective Matched Case-Control Study

      Kayhanian, H., Goode, E., Sclafani, F., Ang, J. E., Gerlinger, M., Gonzalez de Castro, D., Shepherd, S., Peckitt, C., Rao, S., Watkins, D., Chau, I., Cunningham, D. & Starling, N., Mar 2018, In : Clinical colorectal cancer. 17, 1

      Research output: Contribution to journalArticle

    15. Early online date

      HER2 testing of gastro-oesophageal adenocarcinoma: a commentary and guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee

      Wong, N. A. C. S., Amary, F., Butler, R., Byers, R., Gonzalez, D., Haynes, H. R., Ilyas, M., Salto-Tellez, M. & Taniere, P., 08 Feb 2018, In : Journal of Clinical Pathology.

      Research output: Contribution to journalReview article

    16. ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-update on methodological approaches and results interpretation

      Malcikova, J., Tausch, E., Rossi, D., Sutton, L. A., Soussi, T., Zenz, T., Kater, A. P., Niemann, C. U., Gonzalez, D., Davi, F., Gonzalez Diaz, M., Moreno, C., Gaidano, G., Stamatopoulos, K., Rosenquist, R., Stilgenbauer, S., Ghia, P., Pospisilova, S. & European Research Initiative on Chronic Lymphocytic Leukemia (ERIC) — TP53 network, 02 Feb 2018, In : Leukemia. 32, p. 1-11

      Research output: Contribution to journalReview article

    17. Published

      KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer

      Sclafani, F., Chau, I., Cunningham, D., Hahne, J. C., Vlachogiannis, G., Eltahir, Z., Lampis, A., Braconi, C., Kalaitzaki, E., De Castro, D. G., Wotherspoon, A., Capdevila, J., Glimelius, B., Tarazona, N., Begum, R., Lote, H., Hulkki Wilson, S., Mentrasti, G., Brown, G., Tait, D. & 2 othersOates, J. & Valeri, N., 23 Jan 2018, In : Scientific Reports. 8, 1, p. 1445

      Research output: Contribution to journalArticle

    18. Published

      Investigating the feasibility of tumour molecular profiling in gastrointestinal malignancies in routine clinical practice

      Moorcraft, S. Y., Gonzalez de Castro, D., Cunningham, D., Jones, T., Walker, B. A., Peckitt, C., Yuan, L. C., Frampton, M., Begum, R., Eltahir, Z., Wotherspoon, A., Teixeira Mendes, L. S., Hulkki Wilson, S., Gillbanks, A., Baratelli, C., Fotiadis, N., Patel, A., Braconi, C., Valeri, N., Gerlinger, M. & 4 othersRao, S., Watkins, D., Chau, I. & Starling, N., 01 Jan 2018, In : Annals of Oncology. 29, 1, p. 230-236

      Research output: Contribution to journalArticle

    19. 2017
    20. Early online date

      An evaluation of the challenges to developing tumor BRCA1 and BRCA2 testing methodologies for clinical practice

      Ellison, G., Ahdesmäki, M., Luke, S., Waring, P. M., Wallace, A., Wright, R., Röthlisberger, B., Ludin, K., Merkelbach-Bruse, S., Heydt, C., Ligtenberg, M. J. L., Mensenkamp, A. R., de Castro, D. G., Jones, T., Vivancos, A., Kondrashova, O., Pauwels, P., Weyn, C., Hahnen, E., Hauke, J. & 7 othersSoong, R., Lai, Z., Dougherty, B., Carr, T. H., Johnson, J., Mills, J. & Barrett, J. C., 28 Dec 2017, In : Human Mutation. 12 p.

      Research output: Contribution to journalArticle

    21. Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours

      Izquierdo, E., Yuan, L., George, S., Hubank, M., Jones, C., Proszek, P., Shipley, J., Gatz, S. A., Stinson, C., Moore, A. S., Clifford, S. C., Hicks, D., Lindsey, J. C., Hill, R. M., Jacques, T. S., Chalker, J., Thway, K., O'Connor, S., Marshall, L., Moreno, L. & 4 othersPearson, A., Chesler, L., Walker, B. A. & De Castro, D. G., 19 Dec 2017, In : Oncotarget. 8, 67, p. 112036-112050

      Research output: Contribution to journalArticle

    22. Published

      Desmoplastic small round cell tumor evaluation of reverse transcription-polymerase chain reaction and fluorescence in situ hybridization as ancillary molecular diagnostic techniques

      Mohamed, M., Gonzalez, D., Fritchie, K. J., Swansbury, J., Wren, D., Benson, C., Jones, R. L., Fisher, C. & Thway, K., Nov 2017, In : Virchows Archiv. 471, 5, p. 631-640 10 p.

      Research output: Contribution to journalArticle

    23. Predicting response to radical (chemo)radiotherapy with circulating HPV DNA in locally advanced head and neck squamous carcinoma

      Lee, J. Y., Garcia-Murillas, I., Cutts, R. J., De Castro, D. G., Grove, L., Hurley, T., Wang, F., Nutting, C., Newbold, K., Harrington, K., Turner, N. & Bhide, S., 05 Sep 2017, In : British Journal of Cancer. 117, 6, p. 876-883

      Research output: Contribution to journalArticle

    24. Published

      Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients

      Capoluongo, E., Ellison, G., López-Guerrero, J. A., Penault-Llorca, F., Ligtenberg, M. J. L., Banerjee, S., Singer, C., Friedman, E., Markiefka, B., Schirmacher, P., Büttner, R., van Asperen, C. J., Ray-Coquard, I., Endris, V., Kamel-Reid, S., Percival, N., Bryce, J., Röthlisberger, B., Soong, R. & de Castro, D. G., 01 Jun 2017, In : Seminars in Oncology. 44, 3, p. 187-197 11 p.

      Research output: Contribution to journalReview article

    25. High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges

      Langerak, A. W., Brüggemann, M., Davi, F., Darzentas, N., van Dongen, J. J. M., Gonzalez, D., Cazzaniga, G., Giudicelli, V., Lefranc, M-P., Giraud, M., Macintyre, E. A., Hummel, M., Pott, C., Groenen, P. J. T. A., Stamatopoulos, K. & EuroClonality-NGS Consortium, 15 May 2017, In : Journal of Immunology. 198, 10, p. 3765-3774 10 p.

      Research output: Contribution to journalArticle

    26. Molecular profiling of colorectal pulmonary metastases and primary tumours: implications for targeted treatment

      Moorcraft, S. Y., Jones, T., Walker, B. A., Ladas, G., Kalaitzaki, E., Yuan, L., Begum, R., Eltahir, Z., Wotherspoon, A., Fernandez, A. M., Mendes, L. S. T., de Castro, D. G., Wilson, S. H., Proszek, P., To, Y. M., Hawkes, E., Roy, A., Cunningham, D., Rao, S., Watkins, D. & 3 othersStarling, N., Bowcock, A. M. & Chau, I., 11 Apr 2017, In : Oncotarget.

      Research output: Contribution to journalArticle

    27. Early online date

      Mismatch Repair Deficiency, Microsatellite Instability, and Survival: An Exploratory Analysis of the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) Trial

      Smyth, E. C., Wotherspoon, A., Peckitt, C., Gonzalez, D., Hulkki-Wilson, S., Eltahir, Z., Fassan, M., Rugge, M., Valeri, N., Okines, A., Hewish, M., Allum, W., Stenning, S., Nankivell, M., Langley, R. & Cunningham, D., 23 Feb 2017, In : JAMA oncology.

      Research output: Contribution to journalArticle

    28. The spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities

      Noujaim, J., Jones, R. L., Swansbury, J., Gonzalez, D., Benson, C., Judson, I., Fisher, C. & Thway, K., 31 Jan 2017, In : British Journal of Cancer. 10 p.

      Research output: Contribution to journalArticle

    29. 2016
    30. Early online date

      Comprehensive translocation and clonality detection in lymphoproliferative disorders by next generation sequencing

      Wren, D., Walker, B. A., Bruggemann, M., Catherwood, M. A., Pott, C., Stamatopoulos, K., Langerak, A. W., Gonzalez, D. & EuroClonality-NGS Consortium, 20 Oct 2016, In : HAEMATOLOGICA.

      Research output: Contribution to journalArticle

    31. Published

      Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease

      Hiley, C. T., Le Quesne, J., Santis, G., Sharpe, R., de Castro, D. G., Middleton, G. & Swanton, C., 03 Sep 2016, In : Lancet. 388, 10048, p. 1002-11 10 p.

      Research output: Contribution to journalArticle

    32. Sequence Variation in Mature MicroRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients.

      Sclafani, F., Chau, I., Cunningham, D., Lampis, A., Hahne, J. C., Ghidini, M., Lote, H., Zito, D., Tabernero, J., Glimelius, B., Cervantes, A., Begum, R., Gonzalez De Castro, D., Hulkki Wilson, S., Peckitt, C., Eltahir, Z., Wotherspoon, A., Tait, D., Brown, G., Oates, J. & 2 othersBraconi, C. & Valeri, N., 05 Jul 2016, In : Carcinogenesis.

      Research output: Contribution to journalArticle

    33. Published

      A Validation Study for the Use of ROS1 Immunohistochemical Staining in Screening for ROS1 Translocations in Lung Cancer

      Viola, P., Maurya, M., Croud, J., Gazdova, J., Suleman, N., Lim, E., Newsom-Davis, T., Plowman, N., Rice, A., Montero, M. A., Gonzalez de Castro, D., Popat, S. & Nicholson, A. G., Jul 2016, In : Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 11, 7, p. 1029-39 11 p.

      Research output: Contribution to journalArticle

    34. Early online date

      Evaluation of the optimal provision of formalin-fixed, paraffin-embedded material for reverse transcription-PCR in soft-tissue tumour diagnosis.

      Thway, K., Wren, D., Thompson, L., Fisher, C., Gonzalez, D. & Lee, J., 20 May 2016, In : Journal of Clinical Pathology. p. 20-24 5 p.

      Research output: Contribution to journalArticle

    35. Published

      An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors.

      Bikos, V., Karypidou, M., Stalika, E., Baliakas, P., Xochelli, A., Sutton, L-A., Papadopoulos, G., Agathangelidis, A., Papadopoulou, E., Davis, Z., Algara, P., Kanellis, G., Traverse-Glehen, A., Mollejo, M., Anagnostopoulos, A., Ponzoni, M., Gonzalez, D., Pospisilova, S., Matutes, E., Piris, M. A. & 9 othersPapadaki, T., Ghia, P., Rosenquist, R., Oscier, D., Darzentas, N., Tzovaras, D., Belessi, C., Hadzidimitriou, A. & Stamatopoulos, K., 15 Apr 2016, In : Clinical Cancer Research. 22, 8, p. 2032-2040 9 p.

      Research output: Contribution to journalArticle

    36. Published

      Outcomes of patients (pts) with BRAF mutated (BRAF MT) Colorectal Cancer (CRC): The Royal Marsden Experience.

      Kayhanian, H., Goode, E., Ang, J. E., de Castro, D. G., Sclafani, F., Petruckevitch, A., Rao, S., Watkins, D. J., Gerlinger, M., Cunningham, D., Chau, I. & Starling, N., 01 Feb 2016.

      Research output: Contribution to conferenceOther

    37. 3 EGFR mutant circulating tumour DNA detection in advanced lung adenocarcinoma: optimising the application of a ctDNA diagnostic to real world clinical practice

      Pender, A., Rana, S., Izquierdo Delgado, E., Proszek, P., Garcia-Murillas, I., Bhosle, J., O'Brien, M., Palma, J. F., Turner, N. C., Popat, S., Downward, J. & Gonzalez, D., Jan 2016, In : Lung Cancer. 91, Supplement 1, p. S2 1 p.

      Research output: Contribution to journalMeeting abstract

    38. Ancillary molecular analysis in the diagnosis of soft tissue tumours: reassessment of its utility at a specialist centre.

      Vroobel, K., Gonzalez, D., Wren, D., Thompson, L., Swansbury, J., Fisher, C. & Thway, K., 2016, In : Journal of Clinical Pathology. 69, 6, p. 505-510 6 p.

      Research output: Contribution to journalArticle

    39. Published

      p.(L576P) -KIT mutation in GIST: Favorable prognosis and sensitive to imatinib?

      Noujaim, J., Gonzalez, D., Thway, K., Jones, R. L. & Judson, I., 2016, In : CANCER BIOLOGY & THERAPY. 17, 5, p. 543-545 3 p.

      Research output: Contribution to journalArticle

    40. Published

      Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

      Litchfield, K., Levy, M., Dudakia, D., Proszek, P., Shipley, C., Basten, S., Rapley, E., Bishop, D. T., Reid, A., Huddart, R., Broderick, P., Castro, D. G. D., O'Connor, S., Giles, R. H., Houlston, R. S. & Turnbull, C., 2016, In : Nature Communications. 7, 8 p., 13840., 13840

      Research output: Contribution to journalArticle

    41. 2015
    42. Published

      Unique Versus Common: Disease-Biased Immunoglobulin Gene Repertoires Along with Public Antigen Receptor Stereotypes in Marginal Zone B-Cell Lymphoproliferations

      Xochelli, A., Bikos, V., Polychronidou, E., Agathangelidis, A., Charlotte, F., Moschonas, P., Davis, Z., Colombo, M., Roumelioti, M., Sutton, L-A., Groenen, P., Boudjoghra, M., Algara, P., Traverse-Glehen, A., Ferrer, A., Stalika, E., Karypidou, M., Kanellis, G., Kalpadakis, C., Mollejo, M. & 23 othersPangalis, G., Vlamos, P., Amini, R-M., Pospisilova, S., Gonzalez, D., Ponzoni, M., Anagnostopoulos, A., Giudicelli, V., Lefranc, M-P., Espinet, B., Panagiotidis, P., Angel Piris, M., Du, M., Rosenquist, R., Papadaki, T., Belessi, C., Ferrarini, M., Oscier, D., Tzovaras, D., Ghia, P., Davi, F., Hadzidimitriou, A. & Stamatopoulos, K., 03 Dec 2015.

      Research output: Contribution to conferenceOther

    43. Published

      Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.

      Strefford, J. C., Kadalayil, L., Forster, J., Rose-Zerilli, M. J., Parker, A., Lin, T. T., Heppel, N., Norris, K., Gardiner, A., Davies, Z., Gonzalez de Castro, D., Else, M., Steele, A. J., Parker, H., Stankovic, T., Pepper, C., Fegan, C., Baird, D., Collins, A., Catovsky, D. & 1 othersOscier, D. G., Dec 2015, In : Leukemia. 29, 12, p. 2411-2414 4 p.

      Research output: Contribution to journalArticle

    44. Published

      Understanding next generation sequencing in oncology: A guide for oncologists

      Moorcraft, S. Y., Gonzalez, D. & Walker, B. A., Dec 2015, In : Crit Rev Oncol Hematol. 96, 3, p. 463-474 12 p.

      Research output: Contribution to journalArticle

    45. Published

      Focused molecular analysis of small cell lung cancer: feasibility in routine clinical practice. Feasibility in routine clinical practice

      Abdelraouf, F., Sharp, A., Maurya, M., Mair, D., Wotherspoon, A., Leary, A., Gonzalez de Castro, D., Bhosle, J., Nassef, A., Gaafar, T., Popat, S., Yap, T. A. & O'Brien, M., 18 Nov 2015, In : BMC Research Notes. 8, 688, p. 688

      Research output: Contribution to journalArticle

    46. Published

      CRUK SMP2: An Intra- and Inter-site Comparative Study of Cell Line-Based Reference Materials Using Complex NGS Platforms to Transfer a Technology into Routine Practice

      Cummings, R., Rettino, A., Smith, M., Clokie, S., Wood, M., Rehal, P., Williams, I., Dover, K., Walker, B., McBride, D., Ross, M., Butler, R., Bell, J., De Castro, D. G. & Walker, I., Nov 2015, p. 853. 1 p.

      Research output: Contribution to conferenceOther

    47. Published

      Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach.

      Pender, A., Garcia-Murillas, I., Rana, S., Cutts, R. J., Kelly, G., Fenwick, K., Kozarewa, I., Gonzalez de Castro, D., Bhosle, J., O'Brien, M., Turner, N. C., Popat, S. & Downward, J., 28 Sep 2015, In : PLoS One. 10, 9

      Research output: Contribution to journalArticle

    48. Published

      Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing

      Parry, M., Rose-Zerilli, M. J. J., Ljungström, V., Gibson, J., Wang, J., Walewska, R., Parker, H., Parker, A., Davis, Z., Gardiner, A., McIver-Brown, N., Kalpadakis, C., Xochelli, A., Anagnostopoulos, A., Fazi, C., Gonzalez de Castro, D., Dearden, C., Pratt, G., Rosenquist, R., Ashton-Key, M. & 8 othersForconi, F., Collins, A., Ghia, P., Matutes, E., Pangalis, G., Stamatopoulos, K., Oscier, D. & Strefford, J. C., Sep 2015, In : Clinical Cancer Research. 21, 18, p. 4174-4183 10 p.

      Research output: Contribution to journalArticle

    49. Published

      Prognostic role of the LCS-6 KRAS variant in locally advanced rectal cancer: Results of the EXPERT-C trial

      Sclafani, F., Chau, I., Cunningham, D., Peckitt, C., Lampis, A., Hahne, J. C., Braconi, C., Tabernero, J., Glimelius, B., Cervantes, A., Begum, R., De Castro, D. G., Wilson, S. H., Eltahir, Z., Wotherspoon, A., Tait, D., Brown, G., Oates, J. & Valeri, N., Sep 2015, p. S396-S396.

      Research output: Contribution to conferenceOther

    50. Published

      Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer: results of the EXPERT-C trial.

      Sclafani, F., Chau, I., Cunningham, D., Peckitt, C., Lampis, A., Hahne, J. C., Braconi, C., Tabernero, J., Glimelius, B., Cervantes, A., Begum, R., Gonzalez De Castro, D., Hulkki Wilson, S., Eltahir, Z., Wotherspoon, A., Tait, D., Brown, G., Oates, J. & Valeri, N., Sep 2015, In : Annals of Oncology. 26, 9, p. 1936-1941 6 p.

      Research output: Contribution to journalArticle

    51. Published

      Recurrent CDKN1B (p27) mutations in hairy cell leukemia

      Dietrich, S., Huellein, J., Chun-Wei Lee, S., Hutter, B., Gonzalez, D., Jayne, S., Dyer, M. J. S., Oles, M., Else, M., Liu, X., Slabicki, M., Wu, B., Troussard, X., Duerig, J., Andrulis, M., Dearden, C., von Kalle, C., Granzow, M., Jauch, A., Froehling, S. & 10 othersHuber, W., Meggendorfer, M., Haferlach, T., Ho, A. D., Richter, D., Brors, B., Glimm, H., Matutes, E., Wahab, O. A. & Zenz, T., 20 Aug 2015, In : Blood. 126, 8, p. 1005-1008 4 p.

      Research output: Contribution to journalArticle

    52. Published

      A novel multiplex droplet digital PCR approach to KRAS mutation detection in circulating tumor DNA

      Pender, A., Garcia-Murillas, I., Rana, S., de Castro, D. G., Turner, N., Popat, S. & Downward, J., 01 Aug 2015.

      Research output: Contribution to conferenceOther

    53. Published

      The comparative utility of fluorescence in situ hybridization and reverse transcription-polymerase chain reaction in the diagnosis of alveolar rhabdomyosarcoma.

      Thway, K., Wang, J., Wren, D., Dainton, M., Gonzalez, D., Swansbury, J. & Fisher, C., Aug 2015, In : Virchows Archiv. 467, 2, p. 217-224 8 p.

      Research output: Contribution to journalArticle

    54. Published

      Angiomatoid fibrous histiocytoma: comparison of fluorescence in situ hybridization and reverse transcription polymerase chain reaction as adjunct diagnostic modalities

      Thway, K., Gonzalez, D., Wren, D., Dainton, M., Swansbury, J. & Fisher, C., Jun 2015, In : Ann Diagn Pathol. 19, 3, p. 137-142 6 p.

      Research output: Contribution to journalArticle

    55. Published

      CLONAL ORIGINS OF HIGH-HYPERDIPLOID ACUTE LYMPHOBLASTIC LEUKEMIA

      Alpar, D., Wren, D., Mansur, M. B., Potter, N. E., Bateman, C. M., Szczepanski, T., de Castro, D. G., Ford, A. M. & Greaves, M., Jun 2015, p. 199. 1 p.

      Research output: Contribution to conferenceOther

    56. Published

      TRANSLOCATIONS AND CLONALITY DETECTION IN LYMPHOPROLIFERATIVE DISORDERS BY CAPTURE-BASED NEXT-GENERATION SEQUENCING. A PILOT STUDY BY THE EUROCLONALITY-NGS CONSORTIUM

      Wren, D., Walker, B., Bruggemann, M., Catherwood, M., Pott, C., Stamatopoulos, K., Langerak, A. & Gonzalez, D., Jun 2015, p. 106. 1 p.

      Research output: Contribution to conferenceOther

    57. Published

      Variation in pre-PCR processing of FFPE samples leads to discrepancies in BRAF and EGFR mutation detection: a diagnostic RING trial.

      Kapp, J. R., Diss, T., Spicer, J., Gandy, M., Schrijver, I., Jennings, L. J., Li, M. M., Tsongalis, G. J., de Castro, D. G., Bridge, J. A., Wallace, A., Deignan, J. L., Hing, S., Butler, R., Verghese, E., Latham, G. J. & Hamoudi, R. A., Feb 2015, In : Journal of Clinical Pathology. 68, 2, p. 111-118 8 p.

      Research output: Contribution to journalArticle

    58. Published

      Effect of TP53 mutation status on survival in the MAGIC trial

      Smyth, E. C., Wilson, S. H., Nankivell, M. G., de Castro, D. G., Wotherspoon, A., Okines, A. F. C., Langley, R. E., Stenning, S. P. & Cunningham, D., 20 Jan 2015.

      Research output: Contribution to conferenceOther

    59. Published

      FOrMAT: Feasibility of a molecular characterization approach to treatment of patients (pts) with advanced gastrointestinal (GI) tumors

      Moorcraft, S. Y., de Castro, D. G., Cunningham, D., Walker, B. A., Wilson, S. H., Perez, J. D., Peckitt, C., Wotherspoon, A., Begum, R., Valeri, N., Gerlinger, M., Braconi, C., Rao, S., Watkins, D., Chau, I. & Starling, N., 20 Jan 2015.

      Research output: Contribution to conferenceOther

    60. Published

      Prognostic and predictive effect of microsatellite instability (MSI) in MAGIC

      Smyth, E. C., Wilson, S. H., Nankivell, M. G., de Castro, D. G., Wotherspoon, A., Okines, A. F. C., Langley, R. E., Stenning, S. P. & Cunningham, D., 20 Jan 2015.

      Research output: Contribution to conferenceOther

    61. Published

      Prognostic effect of a single nucleotide polymorphism (SNP) in MIR608 in patients with high-risk locally advanced rectal cancer (LARC): Results of the EXPERT-C trial.

      Sclafani, F., Chau, I., Cunningham, D., Lampis, A., Hahne, J., Braconi, C., Peckitt, C., Gonzalez, D., Wilson, S. H., Capdevila, J., Glimelius, B., Cervantes, A., Begum, R., Brown, G., Tait, D. M., Wotherspoon, A., Eltahir, Z., Yusuf-Adam, S., Oates, J. R. & Valeri, N., 20 Jan 2015.

      Research output: Contribution to conferenceOther

    62. Published

      A review of the first 10 months of screening selected patients for the ALK translocation using immunohistochemistry, and their subsequent treatment

      Viola, P., Popat, S., Khan, O., Moule, R., Polychronis, A., Stokoe, J., Dickson, J., Fernandez, A. M., Villegas, I. A., Yancheva, S., de Castro, D. G. & Nicholson, A. G., Jan 2015, p. S32-S33.

      Research output: Contribution to conferenceOther

    63. Clonal origins of ETV6-RUNX1⁺ acute lymphoblastic leukemia: studies in monozygotic twins.

      Alpar, D., Wren, D., Ermini, L., Mansur, M. B., van Delft, F. W., Bateman, C. M., Titley, I., Kearney, L., Szczepanski, T., Gonzalez, D., Ford, A. M., Potter, N. E. & Greaves, M., 2015, In : Leukemia. 29, p. 839-846 8 p.

      Research output: Contribution to journalArticle

    64. 2014
    65. Published

      Deep-Sequencing Reveals the Molecular Landscape of Splenic Marginal Zone Lymphoma: Biological and Clinical Implications

      Rose-Zerilli, M. J. J., Parry, M., Ljungstrom, V., Gibson, J., Wang, J., Walewska, R., Parker, H., Parker, A., Davis, Z., Gardiner, A. C., McIver-Brown, N., Kalpadakis, C. H., Xochelli, A., Anagnostopoulos, A., Fazi, C., de Castro, D. G., Dearden, C., Pratt, G., Rosenquist, R., Ashton-Keys, M. & 8 othersForconi, F., Collins, A., Ghia, P., Matutes, E., Pangalis, G. A., Stamatopoulos, K., Oscier, D. G. & Strefford, J. C., 06 Dec 2014, In : Blood. 124, 21

      Research output: Contribution to journalArticle

    66. Published

      FcγRIIa and FcγRIIIa polymorphisms and cetuximab benefit in the microscopic disease

      Sclafani, F., Gonzalez de Castro, D., Cunningham, D., Hulkki Wilson, S., Peckitt, C., Capdevila, J., Glimelius, B., Roselló Keränen, S., Wotherspoon, A., Brown, G., Tait, D., Begum, R., Thomas, J., Oates, J. & Chau, I., 01 Sep 2014, In : Clinical Cancer Research. 20, 17, p. 4511-4519 9 p.

      Research output: Contribution to journalArticle

    67. Published
    68. Published

      The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors

      Malcikova, J., Stalika, E., Davis, Z., Plevova, K., Trbusek, M., Mansouri, L., Scarfo, L., Baliakas, P., Gardiner, A., Sutton, L-A., Francova, H. S., Agathangelidis, A., Anagnostopoulos, A., Tracy, I., Makris, A., Smardova, J., Ghia, P., Belessi, C., Gonzalez, D., Rosenquist, R. & 3 othersOscier, D., Pospisilova, S. & Stamatopoulos, K., Aug 2014, In : British Journal of Haematology. 166, 4, p. 621-625 5 p.

      Research output: Contribution to journalArticle

    69. Published

      TP53 mutational status and cetuximab benefit in rectal cancer: 5-year results of the EXPERT-C trial.

      Sclafani, F., Gonzalez, D., Cunningham, D., Hulkki Wilson, S., Peckitt, C., Tabernero, J., Glimelius, B., Cervantes, A., Dewdney, A., Wotherspoon, A., Brown, G., Tait, D., Oates, J. & Chau, I., Jul 2014, In : J Natl Cancer Inst. 106, 7

      Research output: Contribution to journalArticle

    70. Published

      A comparison of immunohistochemical assays and FISH in detecting the ALK translocation in diagnostic histological and cytological lung tumor material.

      Le Quesne, J., Maurya, M., Yancheva, S. G., O'Brien, M., Popat, S., Wotherspoon, A. C., de Castro, D. G. & Nicholson, A. G., Jun 2014, In : Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 9, 6, p. 769-774 6 p.

      Research output: Contribution to journalArticle

    71. Published

      A new generation of companion diagnostics: cobas BRAF, KRAS and EGFR mutation detection tests

      Angulo, B., Lopez-Rios, F. & Gonzalez, D., Jun 2014, In : Expert review of molecular diagnostics. 14, 5, p. 517-524 8 p.

      Research output: Contribution to journalArticle

    72. Published

      A comparative study of blood-based KRAS mutation analysis in circulating tumor cells versus circulating plasma DNA to predict primary tumor mutations in lung cancer.

      Lim, E. K. S., Freidin, M. B., Freydina, D. V., Chudasama, D., Leung, M., Popat, S., de Castro, D. G., Rice, A., Anikin, V., Fernandez, A. M. & Nicholson, A. G., 20 May 2014.

      Research output: Contribution to conferenceOther

    73. Published

      A national platform for molecular diagnostics: Results of the Cancer Research UK Stratified Medicine Programme

      Shaw, E., Butler, R., de Castro, D. G., Griffiths, M., Hanby, A., Hair, J., Rae, F., Rogan, J., Morton, D., Brenton, J., Chester, J. D., Johnston, S. R. D., Walker, I. & Johnson, P. W. M., 20 May 2014.

      Research output: Contribution to conferenceOther

    74. Published

      FC gamma RIIa and FC gamma RIIa polymorphisms (SNPs) and cetuximab (C) benefit in the EXPERT-C trial.

      Sclafani, F., Gonzalez de Castro, D., Cunningham, D., Wilson, S. H., Peckitt, C., Capdevila, J., Glimelius, B., Keranen, S. R., Begum, R., Brown, G., Tait, D. M., Wotherspoon, A., Thomas, J., Oates, J. R. & Chau, L., 20 May 2014.

      Research output: Contribution to conferenceOther

    75. Published

      Quality of life (QoL) analysis from the randomized phase III REAL3 trial of epirubicin, oxaliplatin, and capecitabine (EOC) with or without panitumumab (P) in advanced esophagogastric adenocarcinoma.

      Waddell, T. S., Chau, I., Peckitt, C., Gonzalez, D., Wotherspoon, A., Patel, B., Middleton, G. W., Wadsley, J., Ferry, D., Mansoor, W., Crosby, T. D. L., Coxon, F. Y., Smith, D., Waters, J. S., Iveson, T., Falk, S., Slater, S., Okines, A. F. C. & Cunningham, D., 20 May 2014.

      Research output: Contribution to conferenceOther

    76. Published

      RAS mutations and cetuximab in locally advanced rectal cancer: results of the EXPERT-C trial.

      Sclafani, F., Gonzalez, D., Cunningham, D., Hulkki Wilson, S., Peckitt, C., Giralt, J., Glimelius, B., Roselló Keränen, S., Wotherspoon, A., Brown, G., Tait, D., Oates, J. & Chau, I., May 2014, In : European Journal of Cancer. 50, 8, p. 1430-1436 7 p.

      Research output: Contribution to journalArticle

    77. Published

      Investigating Molecular Biomarkers in SCLC

      Abdelraouf, F., de Castro, D. G., Wotherspoon, A., Maurya, M., Mair, D., Bhosle, J., Popat, S. & O'Brien, M., Apr 2014, In : Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 9, 4 , p. S30-S30

      Research output: Contribution to journalMeeting abstract

    78. Published

      External quality assessment of BRAF molecular analysis in melanoma

      Deans, Z. C., Wallace, A., O'Sullivan, B., Purvis, A., Camus, S., Fairley, J. A. & Gonzalez, D., Feb 2014, In : Journal of Clinical Pathology. 67, 2, p. 120-124 5 p.

      Research output: Contribution to journalArticle

    79. Published

      Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms.

      Walker, B. A., Wardell, C. P., Melchor, L., Brioli, A., Johnson, D. C., Kaiser, M. F., Mirabella, F., Lopez-Corral, L., Humphray, S., Murray, L., Ross, M., Bentley, D., Gutiérrez, N. C., Garcia-Sanz, R., San Miguel, J., Davies, F. E., Gonzalez, D. & Morgan, G. J., Feb 2014, In : Leukemia. 28, 2, p. 384-390 7 p.

      Research output: Contribution to journalArticle

    80. Published

      Prognostication in esophagogastric adenocarcinoma (OGA): Factors influencing overall survival (OS) in REAL3.

      Waddell, T. S., Chau, I., Peckitt, C., Patel, B., De Castro, D. G., Wotherspoon, A., Middleton, G. W., Wadsley, J., Ferry, D., Mansoor, W., Crosby, T. D. L., Coxon, F. Y., Smith, D., Waters, J. S., Iveson, T., Falk, S., Slater, S., Okines, A. F. C. & Cunningham, D., 20 Jan 2014.

      Research output: Contribution to conferenceOther

    81. Published

      RAS testing of colorectal carcinoma—a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group

      Wong, N. ACS., Gonzalez de Castro, D., Salto-Tellez, M., Butler, R., Diaz-Cano, S. J., Ilyas, M., Newman, W., Shaw, E., Taniere, P., Walsh, S. V. & Association of Clinical Pathologists Molecular Pathology and Diagnostics Group, 2014, In : Journal of Clinical Pathology. 67, 9, p. 751-757 7 p.

      Research output: Contribution to journalArticle

    82. 2013
    83. Published

      CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia

      Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., Lloyd, B., Gardiner, L-J., Carr, D. F., Pirmohamed, M., Strefford, J. C., Oscier, D. G., de Castro, D. G., Else, M., Catovsky, D. & Pettitt, A. R., 19 Dec 2013, In : Blood. 122, 26, p. 4253-4258 6 p.

      Research output: Contribution to journalArticle

    84. Published

      HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab.

      Sclafani, F., Roy, A., Cunningham, D., Wotherspoon, A., Peckitt, C., Gonzalez de Castro, D., Tabernero, J., Glimelius, B., Cervantes, A., Eltahir, Z., Oates, J. & Chau, I., Dec 2013, In : Annals of Oncology. 24, 12, p. 3123-3128 6 p.

      Research output: Contribution to journalArticle

    85. Published

      A COMPARISON OF FISH AND IMMUNOHISTOCHEMISTRY IN THE DETECTION OF ALK REARRANGEMENT IN LUNG ADENOCARCINOMA

      Le Quesne, J., Maurya, M., De Castro, D. G., Popat, S., Wotherspoon, A. & Nicholson, A., Nov 2013, In : Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 8, p. S1085-S1086

      Research output: Contribution to journalArticle

    86. Published

      Concerns regarding BRAF testing algorithm: reply from authors.

      Gonzalez, D., Fearfield, L., Nathan, P., Tanière, P., Wallace, A., Brown, E., Harwood, C., Marsden, J. & Whittaker, S., Nov 2013, In : British Journal of Dermatology. 169, 5, p. 1168-1170 3 p.

      Research output: Contribution to journalArticle

    87. Published

      FREQUENCY IN EGFR, K-RAS, BRAF AND ALK MUTATIONS IN A COHORT OF CANCERS: ALK TRANSLOCATIONS ARE MORE FREQUENTLY SEEN IN ADVANCED DISEASE

      Lim, E., De Castro, D. G., Popat, S., Shaw, E., Walker, I., Johnson, P., Bamsey, O., Higgins, A., Osadolor, T., Renouf, L. & Nicholson, A. G., Nov 2013, In : Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 8, p. S1222-S1223

      Research output: Contribution to journalArticle

    88. Published

      THE EFFICIENCY OF DETECTION OF KRAS, EGFR AND BRAF MUTATIONS IN PRIMARY LUNG CANCER VIA PERIPHERAL BLOOD CIRCULATING TUMOUR CELLS

      Freidin, M. B., Mair, D., Tay, A., Freydina, D. V., Chudasama, D., Popat, S., Nicholson, A. G., Rice, A., Montero-Fernandez, A., Anikin, V., De Castro, D. G. & Lim, E., Nov 2013, p. S456-S456.

      Research output: Contribution to conferenceOther

    89. Published

      The genomic landscape of oesophagogastric junctional adenocarcinoma

      Chong, I. Y., Cunningham, D., Barber, L. J., Campbell, J., Chen, L., Kozarewa, I., Fenwick, K., Assiotis, I., Guettler, S., Garcia-Murillas, I., Awan, S., Lambros, M., Starling, N., Wotherspoon, A., Stamp, G., Gonzalez-de-Castro, D., Chau, I., Hulkki, S., Nohadani, M., Eltahir, Z. & 6 othersLemnrau, A., Orr, N., Rao, S., Lord, C. J., Ashworth, A. & Benson, M., Nov 2013, In : Journal of Pathology. 231, 3, p. 301-310 10 p.

      Research output: Contribution to journalArticle

    90. Published

      The genomic landscape of oesophagogastric junctional adenocarcinoma

      Chong, I. Y., Cunningham, D., Barber, L. J., Campbell, J., Chen, L., Kozarewa, I., Fenwick, K., Assiotis, I., Guettler, S., Garcia-Murillas, I., Awan, S., Lambros, M., Starling, N., Wotherspoon, A., Stamp, G., Gonzalez-de-Castro, D., Benson, M., Chau, I., Hulkki, S., Nohadani, M. & 6 othersEltahir, Z., Lemnrau, A., Orr, N., Rao, S., Lord, C. J. & Ashworth, A., Nov 2013, In : Journal of Pathology. 231, 3, p. 301-10 10 p.

      Research output: Contribution to journalArticle

    91. Published

      Molecular Stratification of Cancer

      de Castro, D. G., Sep 2013, p. 3. 1 p.

      Research output: Contribution to conferenceOther

    92. Published

      TP53 status may predict benefit from cetuximab in high-risk, locally advanced rectal cancer: Results of the EXPERT-C trial

      Sclafani, F., Gonzalez, D., Cunningham, D., Wilson, S. H., Peckitt, C., Tabernero, J., Glimelius, B., Cervantes, A., Brown, G. & Chau, I., Sep 2013, In : European Journal of Cancer. 49, p. S4-S4

      Research output: Contribution to journalArticle

    93. Published

      A TC classification-based predictor for multiple myeloma using multiplexed real-time quantitative PCR.

      Kaiser, M. F., Walker, B. A., Hockley, S. L., Begum, D. B., Wardell, C. P., Gonzalez, D., Ross, F. M., Davies, F. E. & Morgan, G. J., Aug 2013, In : Leukemia. 27, 8, p. 1754-1757 4 p.

      Research output: Contribution to journalArticle

    94. A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations

      Alrifai, D., Popat, S., Ahmed, M., Gonzalez, D., Nicholson, A. G., du Parcq, J. & Benepal, T., Jun 2013, In : Lung Cancer. 80, 3, p. 339-340 2 p.

      Research output: Contribution to journalArticle

    95. Published

      Biomarker analysis in oesophagogastric cancer: Results from the REAL3 and TransMAGIC trials.

      Okines, A. F., Gonzalez de Castro, D., Cunningham, D., Chau, I., Langley, R. E., Thompson, L. C., Stenning, S. P., Saffery, C., Barbachano, Y., Coxon, F., Middleton, G., Ferry, D., Crosby, T., Madhusudan, S., Wadsley, J., Waters, J., Hall, M., Swinson, D., Robinson, A., Smith, D. & 7 othersReis-Filho, J. S., Waddell, T. S., Puckey, L., Hulkki Wilson, S., Eltahir, Z., Band, M. & Wotherspoon, A., Jun 2013, In : European Journal of Cancer. 49, 9, p. 2116-2125 10 p.

      Research output: Contribution to journalArticle

    96. Published

      Utilizing a collaborative working model to optimize molecular analysis of solid tumors in the Cancer Research UK's Stratified Medicine Programme.

      Walker, I., MacDonald, F., Stuart, H., Butler, R., Ellwood-Thompson, R., Brown, C., Eden, J., de Castro, D. G., Thompson, L., Lillis, S., Mair, D., Cloke, V., Rehal, P., Bell, J., Smith, M., O'Sullivan, B., Taniere, P., Griffiths, M., Johnson, P. W. M. & Team, S. M. P., 20 May 2013.

      Research output: Contribution to conferenceOther

    97. Published

      Comparison of molecular testing methods for the detection of EGFR mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer

      Lopez-Rios, F., Angulo, B., Gomez, B., Mair, D., Martinez, R., Conde, E., Shieh, F., Tsai, J., Vaks, J., Current, R., Lawrence, H. J. & de Castro, D. G., May 2013, In : Journal of Clinical Pathology. 66, 5, p. 381-385 5 p.

      Research output: Contribution to journalArticle

    98. Published

      Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial.

      Waddell, T., Chau, I., Cunningham, D., Gonzalez, D., Okines, A. F., Okines, C., Wotherspoon, A., Saffery, C., Middleton, G., Wadsley, J., Ferry, D., Mansoor, W., Crosby, T., Coxon, F., Smith, D., Waters, J., Iveson, T., Falk, S., Slater, S., Peckitt, C. & 1 othersBarbachano, Y., May 2013, In : Lancet Oncology. 14, 6, p. 481-489 9 p.

      Research output: Contribution to journalArticle

    99. Published

      Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells.

      Walker, B. A., Wardell, C. P., Johnson, D. C., Kaiser, M. F., Begum, D. B., Dahir, N. B., Ross, F. M., Davies, F. E., Gonzalez, D. & Morgan, G. J., 25 Apr 2013, In : Blood. 121, 17, p. 3413-3419 7 p.

      Research output: Contribution to journalArticle

    100. Published

      BRAF mutation testing algorithm for vemurafenib treatment in melanoma: recommendations from an expert panel.

      Gonzalez, D., Fearfield, L., Nathan, P., Tanière, P., Wallace, A., Brown, E., Harwood, C., Marsden, J. & Whittaker, S., Apr 2013, In : British Journal of Dermatology. 168, 4, p. 700-707 8 p.

      Research output: Contribution to journalArticle

    101. Published

      Frequency of mutations and polymorphisms in borderline ovarian tumors of known cancer genes.

      Stemke-Hale, K., Shipman, K., Kitsou-Mylona, I., de Castro, D. G., Hird, V., Brown, R., Flanagan, J., Gabra, H., Mills, G. B., Agarwal, R. & El-Bahrawy, M., Apr 2013, In : Modern Pathology . 26, 4, p. 544-552 9 p.

      Research output: Contribution to journalArticle

    102. Improvement in the quality of molecular analysis of EGFR in non-small-cell lung cancer detected by three rounds of external quality assessment

      Deans, Z. C., Bilbe, N., O'Sullivan, B., Lazarou, L. P., de Castro, D. G., Parry, S., Dodson, A., Taniere, P., Clark, C. & Butler, R., Apr 2013, In : Journal of Clinical Pathology. 66, 4, p. 319-325 7 p.

      Research output: Contribution to journalArticle

    103. Published

      Transformation to "high grade" neuroendocrine carcinoma as an acquired drug resistance mechanism in EGFR-mutant lung adenocarcinoma.

      Popat, S., Wotherspoon, A., Nutting, C. M., Gonzalez, D., Nicholson, A. G. & O'Brien, M., Apr 2013, In : Lung Cancer. 80, 1, p. 1-4 4 p.

      Research output: Contribution to journalArticle

    104. Published

      Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance.

      Gonzalez de Castro, D., Clarke, P. A., Al-Lazikani, B. & Workman, P., Mar 2013, In : Clinical Pharmacology and Therapeutics. 93, 3, p. 252-259 8 p.

      Research output: Contribution to journalArticle

    105. Published

      CLLU1 expression has prognostic value in chronic lymphocytic leukemia after first-line therapy in younger patients and in those with mutated IGHV genes.

      Gonzalez, D., Else, M., Wren, D., Usai, M., Buhl, A. M., Parker, A., Oscier, D., Morgan, G. & Catovsky, D., Feb 2013, In : HAEMATOLOGICA. 98, 2, p. 274-278 5 p.

      Research output: Contribution to journalArticle

    106. Published

      The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial

      Oscier, D. G., Rose-Zerilli, M. J. J., Winkelmann, N., de Castro, D. G., Gomez, B., Forster, J., Parker, H., Parker, A., Gardiner, A., Collins, A., Else, M., Cross, N. C. P., Catovsky, D. & Strefford, J. C., 17 Jan 2013, In : Blood. 121, 3, p. 468-475 8 p.

      Research output: Contribution to journalArticle

    107. Published

      Comparison of Testing Methods for the Detection of BRAF V600E Mutations in Malignant Melanoma: Pre-Approval Validation Study of the Companion Diagnostic Test for Vemurafenib

      Lopez-Rios, F., Angulo, B., Gomez, B., Mair, D., Martinez, R., Conde, E., Shieh, F., Vaks, J., Langland, R., Lawrence, H. J. & de Castro, D. G., 10 Jan 2013, In : PLoS One. 8, 1

      Research output: Contribution to journalArticle

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