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    Interests

     

    Keywords: Vascular Biology; Cardiovascular Medicine; Ophthalmology; Angiogenesis; OIR; Endothelial cells (EC); Microglial cells; ROP; Hypoxia; Hyperoxia; NOS (eNOS and iNOS); BH4; NADPH oxidase; ROS; RNS; Notch/Dll

     

     

    Research Interests

     

    Vascular Biology and Cell-Cell Communication: Endothelial / Mural (Pericyte and Smooth Muscle)/ Microglial Cell cross talk 

    Disease Focus:  Vascular Disease; Endothelial Dysfunction; Retinal Diseases; Retinopathy of Prematurity (ROP); Diabetic Retinopathy

    Signalling Pathways:  Nitric oxide Synthases (NOS); NADPH oxidase; Reactive Oxygen and Nitrogen Species (ROS/RNS); Notch/Delta (Dll), Hypoxia; Hyperoxia and Inflammation

    Model Systems:   Primary cell isolation and culture (endothelial cell, pericyte, microglial); gene delivery (adenoviral, lentiviral); retina as a model of vascular development in health and disease; oxygen-induced retinopathy (OIR); aortic explants; green fluorescent protein (GFP)-tagged fusion construct generation and imaging

     

    Biography

     

    I trained in Biochemistry and Molecular Cell Biology at Queen’s University Belfast, the University of Leeds and the University of Oxford (in the Cardiovascular Medicine Wellcome Trust Centre for Human Genetics, a British Heart Foundation Centre of Excellence). 

    I am currently Senior Lecturer in the Institute for Experimental Medicine where my research focuses on developing strategies to preserve normal vasculature and prevent vascular diseases caused by diabetes and aging, with a particular interest in oxidative stress and its impact on vascular growth/function/recovery and tissue repair.

    My work has been funded externally by, among others, the Wellcome Trust, Fight for Sight, British Heart Foundation and Action Medical Research.

     

    Teaching

    • Cardiovascular Pathobiology & Treatment (BMS2017) – (Co-ordinator)

    • Masters in Medical Research Training Programme

    • Portfolio Mentor – Level 1 & 2 Medical students

     

    Select Lecture titles

    • Vascular Development: Angiogenesis & Vasculogenesis

    • The Eye: Target and Model of Neovascular Disease

    • Retinopathy of Prematurity

    • Vasculogenesis & Angiogenesis I

    • Tumour Angiogenesis

    • Novel Therapeutic Targets for Tumour Angiogenesis: Role of Vessel Normalisation and Metabolism

    • Gene Therapy for the Eye & Cardiovascular Diseases

    • NOTCH in Retinal Angiogenesis  

    Frequent Journals

    • Investigative Opthalmology and Visual Science

      ISSNs: 0146-0404

      Additional searchable ISSN (Electronic): 1552-5783

      Association for Research in Vision and Ophthalmology Inc.

      Scopus rating (2018): CiteScore 3.21 SJR 1.933 SNIP 1.155

      Journal

    • Circulation

      ISSNs: 0009-7322

      Additional searchable ISSN (Electronic): 1524-4539

      Am Heart Assoc

      Scopus rating (2018): CiteScore 9.17 SJR 8.613 SNIP 5.205

      Journal

    • The American journal of pathology

      ISSNs: 0002-9440, 1525-2191

      Additional searchable ISSN (Electronic): 1525-2191

      Elsevier Inc.

      Scopus rating (2018): CiteScore 3.67 SJR 1.92 SNIP 1.098

      Journal

    • Cardiovascular Research

      ISSNs: 0008-6363

      Oxford University Press

      Scopus rating (2018): CiteScore 4.53 SJR 2.227 SNIP 1.371

      Journal

    • Microcirculation

      ISSNs: 1073-9688

      Additional searchable ISSN (Electronic): 1549-8719

      Wiley-Blackwell

      Scopus rating (2018): CiteScore 2.78 SJR 1.399 SNIP 0.875

      Journal

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    Contribution to conference papers, events and activities

    ID: 31059