Emma Kerr

    Emma Kerr

    Senior Research Fellow

    Phone: +44 (0)28 9097 2942

    For media contact email comms.office@qub.ac.uk
    or call +44(0)2890 973091.

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    Research Interests

    METABOLIC REPROGRAMMING: OPPORTUNITIES FOR THERAPEUTIC INTERVENTION

    Cancer cells frequently hijack the metabolic processes hardwired in normal cells to support their enhanced growth, proliferation and spread. Importantly, changes in tumour cell metabolism can present novel vulnerabilities, that when targeted pharmacologically can limit tumour growth; and also alter the sensitivity of these tumour cells to standard-of-care chemotherapies and targeted therapies. Thus, defining the impact of metabolic reprogramming on dictating therapeutic susceptibilities and driving resistance mechanisms is imperative to improving treatment response for cancer patients.

    Our aim is to integrate state-of-the-art cancer models, metabolic analyses and multi-omics platforms to comprehensively map metabolic reprogramming, uncover induced vulnerabilities, mechanisms of drug resistance and novel therapeutic opportunities in defined cancer subtypes (KRASmutantTP53mutant/nullAPCmutant/null), allowing us to better aid in patient stratification, and suggesting novel therapeutic combinations to improve patient outcome.

    Achievements

    Dr Kerr is a CRUK Career Development Fellowship holder

    Willingness to take PhD students

    Yes

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    Frequent Journals

    • Nature Communications

      ISSNs: 2041-1723

      Nature Publishing Group

      Scopus rating (2018): CiteScore 12.19 SJR 5.992 SNIP 2.805

      Journal

    • Cell Death and Differentiation

      ISSNs: 1350-9047

      Nature Publishing Group

      Scopus rating (2018): CiteScore 7.7 SJR 3.98 SNIP 1.881

      Journal

    • Science Translational Medicine

      ISSNs: 1946-6234

      Additional searchable ISSN (Electronic): 1946-6242

      American Association for the Advancement of Science

      Scopus rating (2018): SJR 8.021 SNIP 2.99

      Journal

    • Trends in molecular medicine

      ISSNs: 1471-4914

      Elsevier Limited

      Scopus rating (2018): CiteScore 8.47 SJR 4.502 SNIP 2.395

      Journal

    • European Journal of Cancer

      ISSNs: 0959-8049, 1879-0852

      Additional searchable ISSN (Electronic): 1879-0852

      Elsevier

      Scopus rating (2018): CiteScore 6.15 SJR 3.839 SNIP 2.082

      Journal

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