Frederick Campbell
      Phone: 2759 & RVH 2558

      For media contact email
      or call +44(0)2890 973091.

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      Research Interests

      My work seeks a mechanistic basis for cancer morphology, one of the best established predictors of clinical outcome. To do this, I investigate mechanisms of epithelial assembly into mature glandular architecture in model systems. With others, I defined the role of the apical PTEN/CDC42/PRKCZ pathway in mitotic spindle orientation, epithelial alignment and lumen formation during colonic gland (crypt) assembly. I investigated oncogenic destabilization of these phenomena. I indentified mechanisms underlying cribriform morphology, a histological marker of malignant transformation in human, for the first time. I identified therapeutic targets, conduct translational studies and a cancer clinical trial. I have identified mechanistic links between 2 cancer hallmarks that were previously considered distinct viz genomic instability and cancer morphology.

      Frequent Journals

      • Carcinogenesis

        ISSNs: 0143-3334, 1460-2180

        Additional searchable ISSN (Electronic): 1460-2180

        Oxford University Press

        Scopus rating (2016): CiteScore 5.03 SJR 2.157 SNIP 1.37


      • British Journal of Cancer

        ISSNs: 0007-0920, 1532-1827

        Additional searchable ISSN (Electronic): 1532-1827

        Nature Publishing Group

        Scopus rating (2016): CiteScore 5.78 SJR 2.924 SNIP 1.775


      • Oncogene

        ISSNs: 0950-9232

        Additional searchable ISSN (Electronic): 1476-5594

        Nature Publishing Group

        Scopus rating (2016): CiteScore 6.59 SJR 3.383 SNIP 1.685


      • Journal of Vascular Surgery

        ISSNs: 0741-5214

        Mosby Inc.

        Scopus rating (2016): CiteScore 2.57 SJR 2.091 SNIP 1.915


      • Annals of Surgery

        ISSNs: 0003-4932

        Lippincott Williams and Wilkins

        Scopus rating (2016): CiteScore 5.14 SJR 4.219 SNIP 3.307


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