Frederick Campbell

    Frederick Campbell

    Emeritus Professor, Honorary Professor

    Phone: 2759 & RVH 2558

    For media contact email
    or call +44(0)2890 973091.

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    Research Interests

    My work seeks a mechanistic basis for cancer morphology, one of the best established predictors of clinical outcome. To do this, I investigate mechanisms of epithelial assembly into mature glandular architecture in model systems. With others, I defined the role of the apical PTEN/CDC42/PRKCZ pathway in mitotic spindle orientation, epithelial alignment and lumen formation during colonic gland (crypt) assembly. I investigated oncogenic destabilization of these phenomena. I indentified mechanisms underlying cribriform morphology, a histological marker of malignant transformation in human, for the first time. I identified therapeutic targets, conduct translational studies and a cancer clinical trial. I have identified mechanistic links between 2 cancer hallmarks that were previously considered distinct viz genomic instability and cancer morphology.

    Frequent Journals

    • Carcinogenesis

      ISSNs: 0143-3334, 1460-2180

      Additional searchable ISSN (Electronic): 1460-2180

      Oxford University Press

      Scopus rating (2018): CiteScore 4.33 SJR 1.82 SNIP 1.064


    • British Journal of Cancer

      ISSNs: 0007-0920, 1532-1827

      Additional searchable ISSN (Electronic): 1532-1827

      Nature Publishing Group

      Scopus rating (2018): CiteScore 5.52 SJR 2.848 SNIP 1.654


    • Oncogene

      ISSNs: 0950-9232

      Additional searchable ISSN (Electronic): 1476-5594

      Nature Publishing Group

      Scopus rating (2018): SJR 3.127 SNIP 1.508


    • Journal of Vascular Surgery

      ISSNs: 0741-5214

      Mosby Inc.

      Scopus rating (2018): CiteScore 2.5 SJR 1.757 SNIP 1.529


    • Annals of Surgery

      ISSNs: 0003-4932

      Lippincott Williams and Wilkins

      Scopus rating (2018): CiteScore 4.91 SJR 3.963 SNIP 3.081


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