Geoffrey Gobert

    Geoffrey Gobert

    Senior Lecturer

    Phone: +44 (0)28 9097 2726

    For media contact email comms.office@qub.ac.uk
    or call +44(0)2890 973091.

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    Research Interests

    Dr Gobert is an internationally recognised researcher in the field of helminth biology, and more specifically transcriptional profiling of the blood fluke Schistosoma. Schistosomiasis is a major human disease of tropical and sub-tropical countries. He has published extensively in peer reviewed journals, and contributed to two book chapters, in the fields of parasitology and cellular/molecular biology. His research interests cover a range of fields including Leishmania metabolomics, schistosome calcium homeostasis and drug design, microbiomes and helminths, schistosome induced hepatic granuloma formation and resolution, and helminth tegumental structure/function. Overall his research agenda and expertise falls under the broad banner of host-parasite interactions, and the use of transcriptomics, functional genomics and cellular biology. He has active research collaboration with groups in Australia, USA, Malaysia, Thailand, Laos, China, the Philippines and Mexico. His local research collaborations include the University of Edinburgh, University of Newcastle, Kingston University, Lancaster University and the Sanger Institute.

    Achievements

    Editorial Board

    Experimental Parasitology (since 2009)

    PLoS One (Associate Editor 2011-2015)

    Awards

    2008: NHMRC (National Health and Medical Research Council of Australia) Parasitology Network Travel Bursary.

    2006: Australian Academy of Sciences, Scientific Visits Program.

    2005: Travel Award, NHMRC Australia.

    2002: Howard Florey Centenary Research Fellowship, NHMRC Australia.

    1998: 5th Biennial Goodchild Award, Australian Society for Electron Microscopy.

    1998: Dean’s Award for Excellence, Faculty of Science, Queensland University of Technology.

    Research Statement

    My research is primarily focused on host-pathogen interactions, specifically schistosome parasites and hepatic inflammation/granuloma formation. I am particularly interested in the identification of specific parasite factors that suppress host fibrosis and inflammation, which could represent valuable cellular regenerative options for a broad range of hepatic diseases, beyond those caused by helminths.

    I am interested in exosome biology, and investigating miRNA and protein populations packaged within these structures derived from parasites. The impact of exosomes on the host microenvironment and immunopathology is a particular research priority.

    I lead research projects investigating how the Calcium Signalling Pathway is pivotal to the mode of action of the anthelmintic praziquantel in schistosomes. Specific components within this pathway represent pivotal factors essential for parasite survival after drug administration. The targeting of these components represent an important strategy for the future development of new anthelmintic compounds.

    I strive to answer biological questions investigating the molecular and cellular aspects of parasite disease. I utilise leading research methods such as transcriptomics (microarray and RNAseq), advanced microscopy (including electron microscopy and laser microdissection capture) and gene atlasing, and have published in the areas of immunological signaling and regulation, as associated with parasite induced hepatic fibrosis. I am interested in further expanding my research into antigen processing and presentation in the liver, using in vitro, ex vivo and in vitro techniques I have recently established.

     

    Willingness to take PhD students

    Yes

    PhD projects

    I am open to PhD applications from individuals holding or expecting to hold at least a 2.1 degree (or equivalent) in the fields of immunology, biochemistry or parasitology. A strategy for obtaining funding for a PhD is required. Applicants should be interested in helminthology or parasitology with a view to research pathogens of clinical and/or veterinary significance.

    Frequent Journals

    • PLoS Neglected Tropical Diseases

      ISSNs: 1935-2727

      Public Library of Science

      Scopus rating (2018): SJR 2.669 SNIP 1.538

      Journal

    • International Journal for Parasitology

      ISSNs: 0020-7519

      Additional searchable ISSN (Electronic): 1879-0135

      Elsevier Limited

      Scopus rating (2018): CiteScore 3.44 SJR 1.625 SNIP 1.224

      Journal

    • Parasitology

      ISSNs: 0031-1820

      Additional searchable ISSN (Electronic): 1469-8161

      Cambridge University Press

      Scopus rating (2018): CiteScore 2.23 SJR 0.989 SNIP 0.906

      Journal

    • Parasites & vectors

      ISSNs: 1756-3305

      Additional searchable ISSN (Electronic): 1756-3305

      BioMed Central

      Scopus rating (2018): CiteScore 3.22 SJR 1.565 SNIP 1.27

      Journal

    • PLoS One

      ISSNs: 1932-6203

      Additional searchable ISSN (Electronic): 1932-6203

      Public Library of Science

      Scopus rating (2018): CiteScore 3.02 SJR 1.1 SNIP 1.123

      Journal

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