Geoffrey Gobert

      Dr Geoffrey Gobert

      Senior Lecturer

      Phone: +44 (0)28 9097 2726

      For media contact email comms.office@qub.ac.uk
      or call +44(0)2890 973091.

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      Research Interests

      Dr Gobert is an internationally recognised researcher in the field of helminth biology, and more specifically transcriptional profiling of the blood fluke Schistosoma. Schistosomiasis is a major human disease of tropical and sub-tropical countries. He has published extensively in peer reviewed journals, and has recently contributed to two book chapters, in the fields of parasitology and cellular/molecular biology. His research interests cover a range of fields including Leishmania metabolomics, schistosome calcium homeostasis and drug design, microbiomes and helminths, schistosome induced hepatic granuloma formation and resolution, and helminth tegumental structure/function. Overall his research agenda and expertise falls under the broad banner of host-parasite interactions, and the use of transcriptomics, functional genomics and cellular biology. He has active research collaboration with groups in Australia, USA, Malaysia, China, the Philippines and Mexico. His local research collaborations include the University of Edinburgh, University of Newcastle, Kingston University, Lancaster University and the Sanger Institute.

      Achievements and Distinctions

      Editorial Board

      Experimental Parasitology (since 2009)

      PLoS One (Associate Editor 2011-2015)

      Awards

      2008: NHMRC (National Health and Medical Research Council of Australia) Parasitology Network Travel Bursary.

      2006: Australian Academy of Sciences, Scientific Visits Program.

      2005: Travel Award, NHMRC Australia.

      2002: Howard Florey Centenary Research Fellowship, NHMRC Australia.

      1998: 5th Biennial Goodchild Award, Australian Society for Electron Microscopy.

      1998: Dean’s Award for Excellence, Faculty of Science, Queensland University of Technology.

      Research Statement

      My research is primarily focused on host-pathogen interactions, specifically schistosome parasites and hepatic inflammation/granuloma formation. I am particularly interested in the identification of specific parasite factors that suppress host fibrosis and inflammation, which could represent valuable cellular regenerative options for a broad range of hepatic diseases, beyond those caused by helminths.

      I am interested in exosome biology, and investigating miRNA and protein populations packaged within these structures derived from parasites. The impact of exosomes on the host microenvironment and immunopathology is a particular research priority.

      I lead research projects investigating how the Calcium Signalling Pathway is pivotal to the mode of action of the anthelmintic praziquantel in schistosomes. Specific components within this pathway represent pivotal factors essential for parasite survival after drug administration. The targeting of these components represent an important strategy for the future development of new anthelmintic compounds.

      I strive to answer biological questions investigating the molecular and cellular aspects of parasite disease. I utilise leading research methods such as transcriptomics (microarray and RNAseq), advanced microscopy (including electron microscopy and laser microdissection capture) and gene atlasing, and have published in the areas of immunological signaling and regulation, as associated with parasite induced hepatic fibrosis. I am interested in further expanding my research into antigen processing and presentation in the liver, using in vitro, ex vivo and in vitro techniques I have recently established.

       

      Frequent Journals

      • PLoS neglected tropical diseases

        ISSNs: 1935-2727

        Public Library of Science

        Scopus rating (2016): CiteScore 3.97 SJR 2.381 SNIP 1.508

        Journal

      • Parasitology

        ISSNs: 0031-1820

        Additional searchable ISSN (Electronic): 1469-8161

        Cambridge University Press

        Scopus rating (2016): CiteScore 2.37 SJR 1.053 SNIP 0.921

        Journal

      • International Journal for Parasitology

        ISSNs: 0020-7519

        Additional searchable ISSN (Electronic): 1879-0135

        Elsevier Limited

        Scopus rating (2016): CiteScore 4.17 SJR 1.845 SNIP 1.676

        Journal

      • Trends in Parasitology

        ISSNs: 1471-4922

        Elsevier Limited

        Scopus rating (2016): CiteScore 4.91 SJR 2.508 SNIP 2.068

        Journal

      • Parasites & vectors

        ISSNs: 1756-3305

        Additional searchable ISSN (Electronic): 1756-3305

        BioMed Central

        Scopus rating (2016): CiteScore 3.23 SJR 1.458 SNIP 1.286

        Journal

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