Graham McGeown

    Professor Graham McGeown

    Professor (Education)

    Phone: +44 (0)28 9097 2785

    For media contact email comms.office@qub.ac.uk
    or call +44(0)2890 973091.

    View graph of relations

    Research Statement

    My interests focus on the role played by intracellular Ca2+ in the control of contractility in smooth muscle, particularly in retinal microvessels. This research makes use of microfluorimetry and fast, Ca2+-imaging techniques to investigate how [Ca2+] changes within the cytoplasm and what the functional significance of such changes are. This includes consideration of the effects of localised Ca2+-sparks, cell-wide Ca2+-waves and oscillations, and cell-to-cell spread of Ca2+-signals within microvessels. Much of this work is part of longstanding investigations into how diabetes, a major cause of blindness, affects these small blood vessels, and is carried out with an internationally recognised group of scientists studying the mechanisms responsible for diabetic retinopathy. Other techniques used include electrophysiology, immuno- and histochemistry with confocal microscopy, real time quantitative PCR, and in vitro and in vivo imaging of blood vessels and blood flow in retinal vessels. This multi-faceted approach is revealing new details of physiological and pathophysiological cell signalling within the microvasculature, especially in the context of the early functional changes seen in diabetes.

    Teaching

    MED1015 Systems, people and populations

    MED2013 Physiological basis of clinical practice (Module co-ordinator (Semester 2) 2009-11)

    BMS3005 Advanced Cardiovascular Physiology (Module co-ordinator 1997-2010)

    BMS3006 Advanced Cell Physiology (Module co-ordinator 1997-2009)

    Frequent Journals

    • Investigative Opthalmology and Visual Science

      ISSNs: 0146-0404

      Additional searchable ISSN (Electronic): 1552-5783

      Association for Research in Vision and Ophthalmology Inc.

      Scopus rating (2018): SJR 1.933 SNIP 1.155

      Journal

    • Journal of Physiology

      ISSNs: 0022-3751

      Additional searchable ISSN (Electronic): 1469-7793

      Wiley-Blackwell

      Scopus rating (2018): SJR 1.994 SNIP 1.14

      Journal

    • PLoS One

      ISSNs: 1932-6203

      Additional searchable ISSN (Electronic): 1932-6203

      Public Library of Science

      Scopus rating (2018): SJR 1.1 SNIP 1.123

      Journal

    • Pflügers Archiv - European Journal of Physiology

      ISSNs: 0031-6768

      Additional searchable ISSN (Electronic): 1432-2013

      Springer Verlag

      Scopus rating (2018): SJR 1.548 SNIP 0.893

      Journal

    • Cell Calcium

      ISSNs: 0143-4160

      Churchill Livingstone

      Scopus rating (2018): SJR 1.79 SNIP 0.922

      Journal

    View all »

    View all

    View all

    Contribution to conference papers, events and activities

    ID: 11835