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    Research Statement

    I have been a lecturer within the School of Pharmacy since June 2010 and my research focuses upon proteases with particular emphasis on their role in immune signalling and disease.

    Currently my work focuses upon the DUB/USP17 family of deubiquitinating enzymes where we have shown that USP17 (DUB-3) is induced in response to cytokines, chemokines and growth factors (IL-4, IL-6, IL-8, SCF1, EGF) and that it regulates cell growth and movement. Subsequently, we have demonstrated that USP17 modulates signalling through the Ras/MEK/ERK pathway due to its regulation of Ras processing and localisation. Moreover, we have identified a novel isoform of the protease Ras converting enzyme 1 (RCE1), which is involved in Ras processing, and shown that it is ubiquitinated and that its deubiquitination by USP17 can regulate its localisation and function. We have also shown that USP17 is over-expressed in a range of tumour tissues and we are currently assessing USP17 as a potential cancer therapeutic target.

    In addition, we are examining the role of bacterial proteases potentially involved in the subversion of the host immune response to assess their suitability as therapeutic targets.

     

    Willingness to take PhD students

    Yes

    PhD projects

    Open to PhD applications in the field of the biology, characterisation and therapeutic targeting of mammalian and microbial proteases.
    - USP17 as a therapeutic target in cancer
    - Targeting bacterial proteases as an antimicrobial strategy

    Frequent Journals

    • Journal of Biological Chemistry

      ISSNs: 0021-9258

      Additional searchable ISSN (Electronic): 1083-351X

      American Society for Biochemistry and Molecular Biology Inc.

      Scopus rating (2018): CiteScore 3.92 SJR 2.403 SNIP 1.064

      Journal

    • Biochemical Journal

      ISSNs: 0264-6021

      Additional searchable ISSN (Electronic): 1470-8728

      Portland Press Ltd.

      Scopus rating (2018): CiteScore 4.05 SJR 2.142 SNIP 1.078

      Journal

    • Cancer Research

      ISSNs: 0008-5472

      Additional searchable ISSN (Electronic): 1538-7445

      American Association for Cancer Research Inc.

      Scopus rating (2018): CiteScore 6.94 SJR 4.047 SNIP 1.596

      Journal

    • Biochemical and Biophysical Research Communications

      ISSNs: 0006-291X

      Additional searchable ISSN (Electronic): 1090-2104

      Academic Press Inc.

      Scopus rating (2018): CiteScore 2.69 SJR 0.973 SNIP 0.706

      Journal

    • Oncogene

      ISSNs: 0950-9232

      Additional searchable ISSN (Electronic): 1476-5594

      Nature Publishing Group

      Scopus rating (2018): SJR 3.127 SNIP 1.508

      Journal

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    Contribution to conference papers, events and activities

    ID: 22056