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      Research Statement

      I have been a lecturer within the School of Pharmacy since June 2010 and my research focuses upon proteases with particular emphasis on their role in immune signalling and disease.

      Currently my work focuses upon the DUB/USP17 family of deubiquitinating enzymes where we have shown that USP17 (DUB-3) is induced in response to cytokines, chemokines and growth factors (IL-4, IL-6, IL-8, SCF1, EGF) and that it regulates cell growth and movement. Subsequently, we have demonstrated that USP17 modulates signalling through the Ras/MEK/ERK pathway due to its regulation of Ras processing and localisation. Moreover, we have identified a novel isoform of the protease Ras converting enzyme 1 (RCE1), which is involved in Ras processing, and shown that it is ubiquitinated and that its deubiquitination by USP17 can regulate its localisation and function. We have also shown that USP17 is over-expressed in a range of tumour tissues and we are currently assessing USP17 as a potential cancer therapeutic target.

      In addition, we are examining the role of bacterial proteases potentially involved in the subversion of the host immune response to assess their suitability as therapeutic targets.

       

      Frequent Journals

      • Journal of biological chemistry

        ISSNs: 0021-9258

        Additional searchable ISSN (Electronic): 1083-351X

        American Society for Biochemistry and Molecular Biology Inc.

        Scopus rating (2016): CiteScore 4.17 SJR 2.755 SNIP 1.125

        Journal

      • Cancer Research

        ISSNs: 0008-5472

        Additional searchable ISSN (Electronic): 1538-7445

        American Association for Cancer Research Inc.

        Scopus rating (2016): CiteScore 8.55 SJR 4.753 SNIP 1.986

        Journal

      • Biochemical and Biophysical Research Communications

        ISSNs: 0006-291X

        Additional searchable ISSN (Electronic): 1090-2104

        Academic Press Inc.

        Scopus rating (2016): CiteScore 2.51 SJR 1.091 SNIP 0.688

        Journal

      • Biochemical Journal

        ISSNs: 0264-6021

        Additional searchable ISSN (Electronic): 1470-8728

        Portland Press Ltd.

        Scopus rating (2016): CiteScore 3.63 SJR 2.341 SNIP 0.99

        Journal

      • Oncogene

        ISSNs: 0950-9232

        Additional searchable ISSN (Electronic): 1476-5594

        Nature Publishing Group

        Scopus rating (2016): CiteScore 6.59 SJR 3.383 SNIP 1.685

        Journal

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      Contribution to conference papers, events and activities

      ID: 22056